(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride
- CAS
- 1062580-52-2
- Formula
- C14H24Cl2N2
- MW
- 291.3 g/mol
VQ-012755
Impurity reference standards
Tofacitinib impurities & reference standards
Characterised Tofacitinib impurities, degradation products and related compounds for analytical method development, validation, QC release and regulatory filings.
71reference materials
1nitrosamine impurities
COAHPLC · NMR · MS on request
Parent API: Tofacitinib
477600-75-2 · C16H20N6O
![(3R,4R)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carbaldehyde chemical structure](/media/structures/IWOOTPDLQXSWDV-PWSUYJOCSA-N.svg)
(3R,4R)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carbaldehyde
- CAS
- 2227199-28-0
- Formula
- C14H19N5O
- MW
- 273.33 g/mol
VQ-043917
![(3R,4R)-N,4-Dimethyl-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-amine chemical structure](/media/structures/MZLXAYQSECRJPN-KOLCDFICSA-N.svg)
(3R,4R)-N,4-Dimethyl-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-amine
- CAS
- 2097982-05-1
- Formula
- C13H19N5
- MW
- 245.32 g/mol
VQ-044085
(3S,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride
- CAS
- 1821769-41-8
- Formula
- C14H24Cl2N2
- MW
- 291.3 g/mol
VQ-028422
(3S,4S)-1-Benzyl-N,4-dimethylpiperidin-3-amine Dihydrochloride
- CAS
- 1354486-07-9
- Formula
- C14H24Cl2N2
- MW
- 291.3 g/mol
VQ-012759
![1-(4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)ethan-1-one](/media/pack/1-4-methyl-3-methyl7h-pyrrolo23-dpyrimidin-4-ylaminopiperidin-1-ylethan-1-one.svg?v=3)
1-(4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)ethan-1-one
- CAS
- 344418-61-7
- Formula
- C15H21N5O
- MW
- 287.36 g/mol
VQ-042587
![1,3-Bis((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)propane-1,3-dione chemical structure](/media/structures/CFVCYPAWDKDZTI-VKGYTVAMSA-N.svg)
1,3-Bis((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)propane-1,3-dione
- CAS
- 2504210-41-5
- Formula
- C29H38N10O2
- MW
- 558.7 g/mol
VQ-042586
![2-Chloro-N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine chemical structure](/media/structures/HXKHQCADGODNAT-SCZZXKLOSA-N.svg)
2-Chloro-N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- CAS
- 1616760-97-4
- Formula
- C13H18ClN5
- MW
- 279.77 g/mol
VQ-044084
![3-((3R,4R)-3-(((5R,6S)-5,6-Dihydroxy-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile chemical structure](/media/structures/OTCVGLUFZKDIFV-QDRWXPAPSA-N.svg)
3-((3R,4R)-3-(((5R,6S)-5,6-Dihydroxy-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile
- CAS
- 2101958-24-9
- Formula
- C16H22N6O3
- MW
- 346.38 g/mol
VQ-034309
![3-((3R,4R)-3-(((5S,6R)-5,6-Dihydroxy-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile chemical structure](/media/structures/OTCVGLUFZKDIFV-SUJFGCQRSA-N.svg)
3-((3R,4R)-3-(((5S,6R)-5,6-Dihydroxy-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile
- CAS
- 2101951-13-5
- Formula
- C16H22N6O3
- MW
- 346.38 g/mol
VQ-034312
3-((3R,4R)-3-((6-Aminopyrimidin-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile
- CAS
- 1640971-60-3
- Formula
- C14H20N6O
- MW
- 288.35 g/mol
VQ-034304
![3-((3R,4R)-3-((6,7-Dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile 2-hydroxypropane-1,2,3-tricarboxylate chemical structure](/media/structures/AKIWAQYGFQGDEY-YLAFAASESA-N.svg)
3-((3R,4R)-3-((6,7-Dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile 2-hydroxypropane-1,2,3-tricarboxylate
- CAS
- 1809002-40-1
- Formula
- C22H30N6O8
- MW
- 506.5 g/mol
VQ-028417
![3-((3R,4R)-3-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile chemical structure](/media/structures/RINVSZVUBKMZHU-PWSUYJOCSA-N.svg)
3-((3R,4R)-3-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile
- CAS
- 1527525-58-1
- Formula
- C15H18N6O
- MW
- 298.34 g/mol
VQ-028430
![3-((3R,4R)-4-Methyl-3-(methyl(5-oxo-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile chemical structure](/media/structures/HQAPQPCBGRVLMS-MNOVXSKESA-N.svg)
3-((3R,4R)-4-Methyl-3-(methyl(5-oxo-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile
- CAS
- 2101951-20-4
- Formula
- C16H20N6O2
- MW
- 328.37 g/mol
VQ-028425
![3-((3R,4R)-4-Methyl-3-(methyl(6-oxo-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile chemical structure](/media/structures/FIQMDRYZOUHVEZ-PWSUYJOCSA-N.svg)
3-((3R,4R)-4-Methyl-3-(methyl(6-oxo-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile
- CAS
- 1640971-51-2
- Formula
- C16H20N6O2
- MW
- 328.37 g/mol
VQ-028427
![3-((3R,4R)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanoic Acid chemical structure](/media/structures/NMGRKBVNLVHWSQ-PWSUYJOCSA-N.svg)
3-((3R,4R)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanoic Acid
- CAS
- 2328165-36-0
- Formula
- C16H21N5O3
- MW
- 331.37 g/mol
VQ-028423
![3-(4-(((3R,4R)-1-(2-Cyanoacetyl)-4-methylpiperidin-3-yl)(methyl)amino)-5,6-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3-oxopropanenitrile](/media/pack/3-4-3r4r-1-2-cyanoacetyl-4-methylpiperidin-3-ylmethylamino-56-dihydro-7h-pyrrolo23.svg?v=3)
3-(4-(((3R,4R)-1-(2-Cyanoacetyl)-4-methylpiperidin-3-yl)(methyl)amino)-5,6-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3-oxopropanenitrile
- CAS
- 2459302-82-8
- Formula
- C19H23N7O2
- MW
- 381.4 g/mol
VQ-044086
![3-(4-(((3R,4R)-1-(2-Cyanoacetyl)-4-methylpiperidin-3-yl)(methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3-oxopropanenitrile chemical structure](/media/structures/LAZWNGPGVVGBJZ-HIFRSBDPSA-N.svg)
3-(4-(((3R,4R)-1-(2-Cyanoacetyl)-4-methylpiperidin-3-yl)(methyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3-oxopropanenitrile
- CAS
- 2459302-77-1
- Formula
- C19H21N7O2
- MW
- 379.4 g/mol
VQ-034303
![3-Imino-5-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-2-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carbonyl)-5-oxopentanenitrile chemical structure](/media/structures/MQFPTDMPNUWMKB-ANEUNVMTSA-N.svg)
3-Imino-5-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-2-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carbonyl)-5-oxopentanenitrile
- CAS
- 2102040-00-4
- Formula
- C32H40N12O2
- MW
- 624.7 g/mol
VQ-042584
![4-Chloro-1H-Pyrrolo[2,3-D]Pyrimidine hydrochloride chemical structure](/media/structures/PEBOURCSCAMADU-UHFFFAOYSA-N.svg)
4-Chloro-1H-Pyrrolo[2,3-D]Pyrimidine hydrochloride
- CAS
- 1243346-92-0
- Formula
- C6H5Cl2N3
- MW
- 190.03 g/mol
VQ-013092
![4-Chloro-1H-pyrrolo[2,3-d]pyrimidine potassium salt](/media/pack/4-chloro-1h-pyrrolo23-dpyrimidine-potassium-salt.svg?v=3)
4-Chloro-1H-pyrrolo[2,3-d]pyrimidine potassium salt
- CAS
- 145594-16-7
- Formula
- C6H4ClN3.K
- MW
- 192.67 g/mol
VQ-013093
![4-Chloro-1H-Pyrrolo[2,3-D]Pyrimidine Sodium Salt](/media/pack/4-chloro-1h-pyrrolo23-dpyrimidine-sodium-salt.svg?v=3)
4-Chloro-1H-Pyrrolo[2,3-D]Pyrimidine Sodium Salt
- CAS
- 443642-59-9
- Formula
- C6H4ClN3.Na
- MW
- 176.56 g/mol
VQ-013094
![4-Chloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine chemical structure](/media/structures/LJXVPXRXXVHTBP-UHFFFAOYSA-N.svg)
![5H,6H,7H-Pyrrolo[2,3-d]pyrimidin-6-one chemical structure](/media/structures/NCIZQRMMYUHTDP-UHFFFAOYSA-N.svg)
![Butyl 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanoate chemical structure](/media/structures/IQFJFTIXSPNYQX-ZBFHGGJFSA-N.svg)
Butyl 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanoate
- CAS
- 2227199-31-5
- Formula
- C20H29N5O3
- MW
- 387.5 g/mol
VQ-034305
![Ethyl (E)-3-amino-2-cyano-5-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-5-oxopent-2-enoate chemical structure](/media/structures/DMWDXJYYEFUBGG-DFIXCJIPSA-N.svg)
Ethyl (E)-3-amino-2-cyano-5-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-5-oxopent-2-enoate
- CAS
- 2459302-85-1
- Formula
- C21H27N7O3
- MW
- 425.5 g/mol
VQ-044807
![Ethyl 4-cyano-3-imino-5-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-5-oxopentanoate chemical structure](/media/structures/CGJDKDFXFRVKJG-OJKDSEEBSA-N.svg)
Ethyl 4-cyano-3-imino-5-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-5-oxopentanoate
- CAS
- 2102039-99-4
- Formula
- C21H27N7O3
- MW
- 425.5 g/mol
VQ-028429
![N-((3R,4R)-1-Benzyl-4-methylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine chemical structure](/media/structures/GWMBPMUFLFJILW-BWKNWUBXSA-N.svg)
N-((3R,4R)-1-Benzyl-4-methylpiperidin-3-yl)-N-methyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- CAS
- 923036-30-0
- Formula
- C27H31N5O2S
- MW
- 489.6 g/mol
VQ-028420
![N-((3R,4R)-1,4-Dimethylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine chemical structure](/media/structures/UCFDYZNTNVHTGH-PWSUYJOCSA-N.svg)
N-((3R,4R)-1,4-Dimethylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- CAS
- 2227197-38-6
- Formula
- C14H21N5
- MW
- 259.35 g/mol
VQ-028426
![N-((3S,4S)-1-Benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine chemical structure](/media/structures/UMWNXPTXDOVDFE-MAUKXSAKSA-N.svg)
N-((3S,4S)-1-Benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- CAS
- 1252883-90-1
- Formula
- C20H25N5
- MW
- 335.4 g/mol
VQ-034307
![N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-amine chemical structure](/media/structures/UIYKLGBHPZPMJQ-KOLCDFICSA-N.svg)
N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-amine
- CAS
- 1812890-23-5
- Formula
- C13H21N5
- MW
- 247.34 g/mol
VQ-042580
N-Methyl-N-(3R,4R)-1-cyanoacetyl-4-methylpiperidin-3-yl-2-chloro-7-deazapurine-6-amine
- CAS
- 1616761-00-2
- Formula
- C16H19ClN6O
- MW
- 346.81 g/mol
VQ-028424
FAQs — Tofacitinib impurities
Which Tofacitinib impurities do you supply?
We list 71 Tofacitinib-related reference materials, including process impurities, degradation products, nitrosamine impurities and related compounds. Each is supplied with a COA, and characterisation data (HPLC, 1H-NMR, MS, IR) can be provided on request.
What are Tofacitinib impurity standards used for?
They are used for analytical method development and validation, impurity identification and quantification, forced-degradation and stability studies, and to support ANDA, DMF and other regulatory submissions under ICH Q3A/Q3B (and ICH M7 for mutagenic impurities).
Can you synthesise a Tofacitinib impurity that is not listed?
Yes. Our custom synthesis service can prepare and characterise unlisted impurities, metabolites and labelled analogues from milligram to gram scale. Share the structure or name and required quantity for a quotation.
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