3-Hydroxy-4-Methoxy Benzonitrile

Name: 3-Hydroxy-4-Methoxy Benzonitrile
Brand: Vaqora Chemicals
SKU: VQ-023386

About 3-Hydroxy-4-Methoxy Benzonitrile

Listed under CAS 52805-46-6, 3-Hydroxy-4-Methoxy Benzonitrile is a metabolite or degradation product of Apremilast available from Vaqora Chemicals. Its molecular formula is C8H7NO2 and its molecular weight is 149.15 g/mol. It is also known as 3-hydroxy-4-methoxybenzenecarbonitrile or p-Cyanguajacol.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Apremilast, as well as in QC testing and ANDA/DMF documentation. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling
Fine chemical synthesis

Industries

Related to Apremilast

View every impurity, metabolite and intermediate we list for Apremilast.

Apremilast impurities

Specifications & identifiers

Chemical identifiers
Product name	3-Hydroxy-4-Methoxy Benzonitrile
Catalogue No.	VQ-023386
CAS Number	52805-46-6
IUPAC name	3-hydroxy-4-methoxybenzonitrile
Molecular formula	C₈H₇NO₂
Molecular weight	149.15 g/mol
Exact mass	149.0477
Grade	Reference Standard
HSN code	38229090
InChIKey	ASQHIJLQYYFUDN-UHFFFAOYSA-N
SMILES	COC1=C(C=C(C=C1)C#N)O
PubChem CID	4912822

Physical properties
Physical form	Solid
LogP (XLogP3)	1.2
H-bond donors / acceptors	1 / 3
TPSA	53.3 Å²

Safety & hazard information (GHS)

Corrosive

Toxic

Harmful / irritant

Signal word: Danger

Hazard statements

H301+H311+H331Toxic if swallowed, in contact with skin or if inhaled
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation

Precautionary statements: P261, P262, P264, P264 + P265, P270, P271, P280, P301 + P316, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P305 + P354 + P338, P316, P317, P319, P321, P330, P332 + P317, P337 + P317, P361 + P364, P362 + P364, P403 + P233, P405

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 3-Hydroxy-4-Methoxy Benzonitrile?

The CAS Registry Number of 3-Hydroxy-4-Methoxy Benzonitrile is 52805-46-6. It is also known as 3-hydroxy-4-methoxybenzenecarbonitrile, p-Cyanguajacol, 2-methoxy-5-cyanophenol.

What is the molecular formula and molecular weight of 3-Hydroxy-4-Methoxy Benzonitrile?

3-Hydroxy-4-Methoxy Benzonitrile has the molecular formula C8H7NO2 and a molecular weight of 149.15 g/mol. Its IUPAC name is 3-hydroxy-4-methoxybenzonitrile.

What is 3-Hydroxy-4-Methoxy Benzonitrile used for?

3-Hydroxy-4-Methoxy Benzonitrile is supplied as a characterised reference material related to Apremilast. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 3-Hydroxy-4-Methoxy Benzonitrile can I order?

We supply 3-Hydroxy-4-Methoxy Benzonitrile in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 3-Hydroxy-4-Methoxy Benzonitrile?

Yes. Every lot of 3-Hydroxy-4-Methoxy Benzonitrile is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 3-Hydroxy-4-Methoxy Benzonitrile be shipped internationally?

Yes. 3-Hydroxy-4-Methoxy Benzonitrile is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.