(3R,4S)-3-Hydroxy-4-phenyl-2-azetidinone

Name: (3R,4S)-3-Hydroxy-4-phenyl-2-azetidinone
Brand: Vaqora Chemicals
SKU: VQ-048052

About (3R,4S)-3-Hydroxy-4-phenyl-2-azetidinone

(3R,4S)-3-Hydroxy-4-phenyl-2-azetidinone (CAS 132127-34-5) is a metabolite or degradation product of Docetaxel offered by Vaqora Chemicals. With the molecular formula C9H9NO2, it has a molar mass of 163.17 g/mol. Systematically, it is named (3R,4S)-3-hydroxy-4-phenylazetidin-2-one. It is also known as 2-Azetidinone, 3-hydroxy-4-phenyl-, (3R,4S)- or (3R-cis)-3-Hydroxy-4-phenyl-2-azetidinone.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Docetaxel, as well as in QC testing and ANDA/DMF documentation. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Docetaxel

View every impurity, metabolite and intermediate we list for Docetaxel.

Docetaxel impurities

Specifications & identifiers

Chemical identifiers
Product name	(3R,4S)-3-Hydroxy-4-phenyl-2-azetidinone
Catalogue No.	VQ-048052
CAS Number	132127-34-5
IUPAC name	(3R,4S)-3-hydroxy-4-phenylazetidin-2-one
Molecular formula	C₉H₉NO₂
Molecular weight	163.17 g/mol
Exact mass	163.0633
Grade	Reference Standard
HSN code	38229090
InChIKey	FBZSDKXFQUKDLD-JGVFFNPUSA-N
SMILES	C1=CC=C(C=C1)[C@H]2[C@H](C(=O)N2)O
PubChem CID	10219589

Physical properties
Physical form	Solid
LogP (XLogP3)	0.2
H-bond donors / acceptors	2 / 2
TPSA	49.3 Å²
Synonyms	2-Azetidinone, 3-hydroxy-4-phenyl-, (3R,4S)-, (3R-cis)-3-Hydroxy-4-phenyl-2-azetidinone, (3R,4S)-3-hydroxy-4-phenyl-azetidin-2-one, 3-Hydroxy-4-phenylazetidin-2-one, (3R,4S)-, 2-Azetidinone,3-hydroxy-4-phenyl-, (3R,4S)-, 2-Azetidinone, 3-hydroxy-4-phenyl-, (3R-cis)-

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation

Precautionary statements: P264, P264 + P265, P280, P302 + P352, P305 + P351 + P338, P321, P332 + P317, P337 + P317, P362 + P364

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of (3R,4S)-3-Hydroxy-4-phenyl-2-azetidinone?

The CAS Registry Number of (3R,4S)-3-Hydroxy-4-phenyl-2-azetidinone is 132127-34-5. It is also known as 2-Azetidinone, 3-hydroxy-4-phenyl-, (3R,4S)-, (3R-cis)-3-Hydroxy-4-phenyl-2-azetidinone, (3R,4S)-3-hydroxy-4-phenyl-azetidin-2-one.

What is the molecular formula and molecular weight of (3R,4S)-3-Hydroxy-4-phenyl-2-azetidinone?

(3R,4S)-3-Hydroxy-4-phenyl-2-azetidinone has the molecular formula C9H9NO2 and a molecular weight of 163.17 g/mol. Its IUPAC name is (3R,4S)-3-hydroxy-4-phenylazetidin-2-one.

What is (3R,4S)-3-Hydroxy-4-phenyl-2-azetidinone used for?

(3R,4S)-3-Hydroxy-4-phenyl-2-azetidinone is supplied as a characterised reference material related to Docetaxel. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of (3R,4S)-3-Hydroxy-4-phenyl-2-azetidinone can I order?

We supply (3R,4S)-3-Hydroxy-4-phenyl-2-azetidinone in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with (3R,4S)-3-Hydroxy-4-phenyl-2-azetidinone?

Yes. Every lot of (3R,4S)-3-Hydroxy-4-phenyl-2-azetidinone is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can (3R,4S)-3-Hydroxy-4-phenyl-2-azetidinone be shipped internationally?

Yes. (3R,4S)-3-Hydroxy-4-phenyl-2-azetidinone is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.