4-Amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine 151266-23-8

Name: 4-Amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine
Brand: Vaqora Chemicals
SKU: VQ-037617

About 4-Amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine

4-Amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine (CAS 151266-23-8) is a process intermediate or related compound of Ibrutinib offered by Vaqora Chemicals. Formula C5H4IN5, molecular weight 261.02 g/mol. The IUPAC name is 3-iodo-2H-pyrazolo[3,4-d]pyrimidin-4-amine. It is also known as 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine or 3-iodo-1H-pyrazolo(3,4-d)pyrimidin-4-amine.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Process chemists and analysts use it when developing synthetic routes to Ibrutinib, tracking process-related impurities and validating analytical methods. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development
Fine chemical synthesis

Industries

Related to Ibrutinib

View every impurity, metabolite and intermediate we list for Ibrutinib.

Ibrutinib impurities

Specifications & identifiers

Chemical identifiers
Product name	4-Amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine
Catalogue No.	VQ-037617
CAS Number	151266-23-8
IUPAC name	3-iodo-2H-pyrazolo[3,4-d]pyrimidin-4-amine
Molecular formula	C₅H₄IN₅
Molecular weight	261.02 g/mol
Exact mass	260.9511
HSN code	2933
InChIKey	HQAIUXZORKJOJY-UHFFFAOYSA-N
SMILES	C1=NC2=NNC(=C2C(=N1)N)I
PubChem CID	1519489

Physical properties
Physical form	Solid
LogP (XLogP3)	0.5
H-bond donors / acceptors	2 / 4
TPSA	80.5 Å²
Synonyms	3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine, 3-iodo-1H-pyrazolo(3,4-d)pyrimidin-4-amine, 3-iodo-1H-pyrazolo{3,4-d}pyrimidin-4-amine, 4-Amino-3-iodopyrazolo[3,4-d]pyrimidine, 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-iodo-, 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine, 3-iodo- 3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE, 7-iodo-7-deaza-8-aza-adenine, 1H-Pyrazolo[3,4-d]pyrimidin-4-amine,, 3-iodo-4-Aminopyrazolo[3,4-d]pyridine

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 4-Amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine?

The CAS Registry Number of 4-Amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine is 151266-23-8. It is also known as 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine, 3-iodo-1H-pyrazolo(3,4-d)pyrimidin-4-amine, 3-iodo-1H-pyrazolo{3,4-d}pyrimidin-4-amine.

What is the molecular formula and molecular weight of 4-Amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine?

4-Amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine has the molecular formula C5H4IN5 and a molecular weight of 261.02 g/mol. Its IUPAC name is 3-iodo-2H-pyrazolo[3,4-d]pyrimidin-4-amine.

What is 4-Amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine used for?

4-Amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine is supplied as a characterised reference material related to Ibrutinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 4-Amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine can I order?

We supply 4-Amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 4-Amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine?

Yes. Every lot of 4-Amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 4-Amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine be shipped internationally?

Yes. 4-Amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.