4-Hydroxy-6,7-dimethoxyqunioline

Name: 4-Hydroxy-6,7-dimethoxyqunioline
Brand: Vaqora Chemicals
SKU: VQ-021037

About 4-Hydroxy-6,7-dimethoxyqunioline

4-Hydroxy-6,7-dimethoxyqunioline (CAS 13425-93-9) is a metabolite or degradation product of Cabozantinib offered by Vaqora Chemicals. Formula C11H11NO3, molecular weight 205.21 g/mol. Its systematic (IUPAC) name is 6,7-dimethoxy-1H-quinolin-4-one. It is also known as Cabozantinib Hydroxy Analog or 6,7-Dimethoxy-4-hydroxyquinoline.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Warning” with 6 hazard statements. Review the Safety Data Sheet before use.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Cabozantinib, as well as in QC testing and ANDA/DMF documentation. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

We offer 4-Hydroxy-6,7-dimethoxyqunioline in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling
Fine chemical synthesis

Industries

Related to Cabozantinib

View every impurity, metabolite and intermediate we list for Cabozantinib.

Cabozantinib impurities

Specifications & identifiers

Chemical identifiers
Product name	4-Hydroxy-6,7-dimethoxyqunioline
Catalogue No.	VQ-021037
CAS Number	13425-93-9
IUPAC name	6,7-dimethoxy-1H-quinolin-4-one
Molecular formula	C₁₁H₁₁NO₃
Molecular weight	205.21 g/mol
Exact mass	205.0739
Grade	Reference Standard
HSN code	38229090
InChIKey	QOGPNCUTXVZQSL-UHFFFAOYSA-N
SMILES	COC1=C(C=C2C(=C1)C(=O)C=CN2)OC
PubChem CID	459611

Physical properties
Physical form	Solid
LogP (XLogP3)	1.5
H-bond donors / acceptors	1 / 4
TPSA	47.6 Å²
Synonyms	Cabozantinib Hydroxy Analog, 6,7-Dimethoxy-4-hydroxyquinoline, 4(1H)-Quinolinone, 6,7-dimethoxy-, 4-Quinolinol, 6,7-dimethoxy-, 6,7-dimethoxy-4(1H)-quinolinone, 6,7-dimethoxyquinolin-4-ol, 6,7-dimethoxyquinolin-4(1H)-one, 6,7-Dimethoxy-4-quinolinol, 6,7-dimethoxy-1,4-dihydroquinolin-4-one, 6,7-Dimethoxy-1,4-dihydro-4-quinolinone, 6,7-Dimethoxy-quinolin-4-ol

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H341Suspected of causing genetic defects
H361Suspected of damaging fertility or the unborn child

Precautionary statements: P203, P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P318, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 4-Hydroxy-6,7-dimethoxyqunioline?

The CAS Registry Number of 4-Hydroxy-6,7-dimethoxyqunioline is 13425-93-9. It is also known as Cabozantinib Hydroxy Analog, 6,7-Dimethoxy-4-hydroxyquinoline, 4(1H)-Quinolinone, 6,7-dimethoxy-.

What is the molecular formula and molecular weight of 4-Hydroxy-6,7-dimethoxyqunioline?

4-Hydroxy-6,7-dimethoxyqunioline has the molecular formula C11H11NO3 and a molecular weight of 205.21 g/mol. Its IUPAC name is 6,7-dimethoxy-1H-quinolin-4-one.

What is 4-Hydroxy-6,7-dimethoxyqunioline used for?

4-Hydroxy-6,7-dimethoxyqunioline is supplied as a characterised reference material related to Cabozantinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 4-Hydroxy-6,7-dimethoxyqunioline can I order?

We supply 4-Hydroxy-6,7-dimethoxyqunioline in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 4-Hydroxy-6,7-dimethoxyqunioline?

Yes. Every lot of 4-Hydroxy-6,7-dimethoxyqunioline is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 4-Hydroxy-6,7-dimethoxyqunioline be shipped internationally?

Yes. 4-Hydroxy-6,7-dimethoxyqunioline is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.