4-Hydroxy Estrone

Name: 4-Hydroxy Estrone
Brand: Vaqora Chemicals
SKU: VQ-030575

About 4-Hydroxy Estrone

4-Hydroxy Estrone is a metabolite or degradation product of Estriol carrying the CAS registry number 3131-23-5. The compound has the formula C18H22O3, corresponding to a molecular weight of 286.4 g/mol. The IUPAC name is (8R,9S,13S,14S)-3,4-dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one. Common synonyms include 3,4-Dihydroxyestra-1,3,5(10)-trien-17-one and 3,4-dihydroxy-1,3,5(10)-estratrien-17-one.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Handle it with standard laboratory precautions and appropriate personal protective equipment.

Analytical teams use this compound to identify metabolites and degradants of Estriol, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 4-Hydroxy Estrone is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Estriol

View every impurity, metabolite and intermediate we list for Estriol.

Estriol impurities

Specifications & identifiers

Chemical identifiers
Product name	4-Hydroxy Estrone
Catalogue No.	VQ-030575
CAS Number	3131-23-5
IUPAC name	(8R,9S,13S,14S)-3,4-dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one
Molecular formula	C₁₈H₂₂O₃
Molecular weight	286.4 g/mol
Exact mass	286.1569
Grade	Reference Standard
HSN code	38229090
InChIKey	XQZVQQZZOVBNLU-QDTBLXIISA-N
SMILES	C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CCC4=C3C=CC(=C4O)O
PubChem CID	9971251

Physical properties
Physical form	Solid
LogP (XLogP3)	2.8
H-bond donors / acceptors	2 / 3
TPSA	57.5 Å²
Synonyms	3,4-Dihydroxyestra-1,3,5(10)-trien-17-one, 3,4-dihydroxy-1,3,5(10)-estratrien-17-one, 4-OHE1, 4-OHE(1), 3,4-dihydroxy-estra-1,3,5(10)-trien-17-one, 1,3,5(10)-Estratriene-3,4-diol-17-one, estra-1,3,5(10)-triene-3,4-diol-17-one

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 4-Hydroxy Estrone?

The CAS Registry Number of 4-Hydroxy Estrone is 3131-23-5. It is also known as 3,4-Dihydroxyestra-1,3,5(10)-trien-17-one, 3,4-dihydroxy-1,3,5(10)-estratrien-17-one, 4-OHE1.

What is the molecular formula and molecular weight of 4-Hydroxy Estrone?

4-Hydroxy Estrone has the molecular formula C18H22O3 and a molecular weight of 286.4 g/mol. Its IUPAC name is (8R,9S,13S,14S)-3,4-dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one.

What is 4-Hydroxy Estrone used for?

4-Hydroxy Estrone is supplied as a characterised reference material related to Estriol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 4-Hydroxy Estrone can I order?

We supply 4-Hydroxy Estrone in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 4-Hydroxy Estrone?

Yes. Every lot of 4-Hydroxy Estrone is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 4-Hydroxy Estrone be shipped internationally?

Yes. We export 4-Hydroxy Estrone worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.