4-Nitroso Sulfamethoxazole

Name: 4-Nitroso Sulfamethoxazole
Brand: Vaqora Chemicals
SKU: VQ-033979

About 4-Nitroso Sulfamethoxazole

Vaqora Chemicals supplies 4-Nitroso Sulfamethoxazole, a nitrosamine impurity of Sulfamethoxazole registered under CAS number 131549-85-4. Formula C10H9N3O4S, molecular weight 267.26 g/mol. Its systematic (IUPAC) name is N-(5-methyl-1,2-oxazol-3-yl)-4-nitrosobenzenesulfonamide. It is also known as nitroso sulphamethoxazole or SMX-NO.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Warning” with 4 hazard statements. Review the Safety Data Sheet before use.

It is used as a reference standard for trace-level detection and quantitation of nitrosamine impurities by LC-MS/MS or GC-MS, supporting nitrosamine risk assessments for Sulfamethoxazole, method validation (AMV) and regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

We offer 4-Nitroso Sulfamethoxazole in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Sulfamethoxazole

View every impurity, metabolite and intermediate we list for Sulfamethoxazole.

Sulfamethoxazole impurities

Specifications & identifiers

Chemical identifiers
Product name	4-Nitroso Sulfamethoxazole
Catalogue No.	VQ-033979
CAS Number	131549-85-4
IUPAC name	N-(5-methyl-1,2-oxazol-3-yl)-4-nitrosobenzenesulfonamide
Molecular formula	C₁₀H₉N₃O₄S
Molecular weight	267.26 g/mol
Exact mass	267.0314
Grade	Reference Standard
HSN code	38229090
InChIKey	GHNQGDUYHCZZPT-UHFFFAOYSA-N
SMILES	CC1=CC(=NO1)NS(=O)(=O)C2=CC=C(C=C2)N=O
PubChem CID	125483

Physical properties
Physical form	Solid
LogP (XLogP3)	0.9
H-bond donors / acceptors	1 / 7
TPSA	110 Å²
Synonyms	N-(5-Methyl-3-isoxazolyl)-4-nitrosobenzenesulfonamide, Benzenesulfonamide, N-(5-methyl-3-isoxazolyl)-4-nitroso-, nitroso sulphamethoxazole, SMX-NO, N-(5-methylisoxazol-3-yl)-4-nitrosobenzenesulfonamide, N-(5-methyl-1,2-oxazol-3-yl)-4-nitrosobenzene-1-sulfonamide, 4-nitroso-SMX, Nitroso-sulfamethoxazole, 4-Nitroso Sulfamethoxazole, > 90per cent, N-(5-methylisoxazol-3-yl)-4-nitroso-benzenesulfonamide

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P272, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P333 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 4-Nitroso Sulfamethoxazole?

The CAS Registry Number of 4-Nitroso Sulfamethoxazole is 131549-85-4. It is also known as N-(5-Methyl-3-isoxazolyl)-4-nitrosobenzenesulfonamide, Benzenesulfonamide, N-(5-methyl-3-isoxazolyl)-4-nitroso-, nitroso sulphamethoxazole.

What is the molecular formula and molecular weight of 4-Nitroso Sulfamethoxazole?

4-Nitroso Sulfamethoxazole has the molecular formula C10H9N3O4S and a molecular weight of 267.26 g/mol. Its IUPAC name is N-(5-methyl-1,2-oxazol-3-yl)-4-nitrosobenzenesulfonamide.

What is 4-Nitroso Sulfamethoxazole used for?

4-Nitroso Sulfamethoxazole is supplied as a characterised reference material related to Sulfamethoxazole. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 4-Nitroso Sulfamethoxazole can I order?

We supply 4-Nitroso Sulfamethoxazole in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 4-Nitroso Sulfamethoxazole?

Yes. Every lot of 4-Nitroso Sulfamethoxazole is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 4-Nitroso Sulfamethoxazole be shipped internationally?

Yes. 4-Nitroso Sulfamethoxazole is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.