N-Hydroxy Sulfamethoxazole

Name: N-Hydroxy Sulfamethoxazole
Brand: Vaqora Chemicals
SKU: VQ-042304

About N-Hydroxy Sulfamethoxazole

Listed under CAS 114438-33-4, N-Hydroxy Sulfamethoxazole is a metabolite or degradation product of Sulfamethoxazole available from Vaqora Chemicals. Its molecular formula is C10H11N3O4S and its molecular weight is 269.28 g/mol. Its systematic (IUPAC) name is 4-(hydroxyamino)-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide. Common synonyms include Sulfamethoxazole hydroxylamine and Smx-HA.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Analytical teams use this compound to identify metabolites and degradants of Sulfamethoxazole, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, N-Hydroxy Sulfamethoxazole is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Sulfamethoxazole

View every impurity, metabolite and intermediate we list for Sulfamethoxazole.

Sulfamethoxazole impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Hydroxy Sulfamethoxazole
Catalogue No.	VQ-042304
CAS Number	114438-33-4
IUPAC name	4-(hydroxyamino)-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide
Molecular formula	C₁₀H₁₁N₃O₄S
Molecular weight	269.28 g/mol
Exact mass	269.047
Grade	Reference Standard
HSN code	38229090
InChIKey	MJAMPGKHIZXVFJ-UHFFFAOYSA-N
SMILES	CC1=CC(=NO1)NS(=O)(=O)C2=CC=C(C=C2)NO
PubChem CID	114821

Physical properties
Physical form	Solid
LogP (XLogP3)	1.1
H-bond donors / acceptors	3 / 7
TPSA	113 Å²
Synonyms	Sulfamethoxazole hydroxylamine, Smx-HA, sulphamethoxazole hydroxylamine, 4-(Hydroxyamino)-N-(5-methyl-3-isoxazolyl)benzenesulfonamide, Benzenesulfonamide, 4-(hydroxyamino)-N-(5-methyl-3-isoxazolyl)-, 4-(hydroxyamino)-N-(5-methylisoxazol-3-yl)benzenesulfonamide, Sulfamethoxazole N4-Hydroxylamine, 4-(hydroxyamino)-N-(5-methyl-1,2-oxazol-3-yl)benzene-1-sulfonamide, Hydroxylamine-SMX, Hydroxylamine of sulfamethoxazole, Sulfamethoxazole-N4-hydroxylamine, 3-(4-hydroxylamino phenylsulfonamido)-5-methylisoxazole

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P272, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P333 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Hydroxy Sulfamethoxazole?

The CAS Registry Number of N-Hydroxy Sulfamethoxazole is 114438-33-4. It is also known as Sulfamethoxazole hydroxylamine, Smx-HA, sulphamethoxazole hydroxylamine.

What is the molecular formula and molecular weight of N-Hydroxy Sulfamethoxazole?

N-Hydroxy Sulfamethoxazole has the molecular formula C10H11N3O4S and a molecular weight of 269.28 g/mol. Its IUPAC name is 4-(hydroxyamino)-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide.

What is N-Hydroxy Sulfamethoxazole used for?

N-Hydroxy Sulfamethoxazole is supplied as a characterised reference material related to Sulfamethoxazole. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Hydroxy Sulfamethoxazole can I order?

We supply N-Hydroxy Sulfamethoxazole in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Hydroxy Sulfamethoxazole?

Yes. Every lot of N-Hydroxy Sulfamethoxazole is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Hydroxy Sulfamethoxazole be shipped internationally?

Yes. N-Hydroxy Sulfamethoxazole is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.