42-O-tert-Butyldimethylsilyloxyethyl Rapamycin 159351-68-5

Name: 42-O-tert-Butyldimethylsilyloxyethyl Rapamycin
Brand: Vaqora Chemicals
SKU: VQ-030640

About 42-O-tert-Butyldimethylsilyloxyethyl Rapamycin

42-O-tert-Butyldimethylsilyloxyethyl Rapamycin is an impurity of Everolimus carrying the CAS registry number 159351-68-5. Formula C59H97NO14Si, molecular weight 1072.5 g/mol.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

This Everolimus impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

We offer 42-O-tert-Butyldimethylsilyloxyethyl Rapamycin in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide. SDS and detailed specification sheets can be requested with your quotation.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Everolimus

View every impurity, metabolite and intermediate we list for Everolimus.

Everolimus impurities

Specifications & identifiers

Chemical identifiers
Product name	42-O-tert-Butyldimethylsilyloxyethyl Rapamycin
Catalogue No.	VQ-030640
CAS Number	159351-68-5
IUPAC name	(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-12-[(2R)-1-[(1S,3R,4R)-4-[2-[tert-butyl(dimethyl)silyl]oxyethoxy]-3-methoxycyclohexyl]propan-2-yl]-1,18-dihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
Molecular formula	C₅₉H₉₇NO₁₄Si
Molecular weight	1072.5 g/mol
Exact mass	1071.6678
Grade	Reference Standard
HSN code	38229090
InChIKey	OCAIMYVVCQFDKI-JFPHMNFRSA-N
SMILES	C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OCCO[Si](C)(C)C(C)(C)C)C)/C)O)OC)C)C)/C)OC
PubChem CID	71608050

Physical properties
Physical form	Solid
H-bond donors / acceptors	2 / 14
TPSA	194 Å²
Synonyms	40-O-(2-(t-butyldimethylsilyl)oxy)ethyl-rapamycin, 40-O-[2-(t-butyldimethylsilyl)oxy]ethyl-rapamycin, Rapamycin 42-[2-(tert-butyldimethylsilyloxy)ethyl] ether, Rapamycin, 42-O-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-, 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine, rapamycin deriv.

Safety & hazard information (GHS)

Toxic

Health hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H311Toxic in contact with skin
H331Toxic if inhaled
H360May damage fertility or the unborn child
H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements: P203, P260, P261, P262, P264, P270, P271, P280, P301 + P316, P302 + P352, P304 + P340, P316, P318, P319, P321, P330, P361 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 42-O-tert-Butyldimethylsilyloxyethyl Rapamycin?

The CAS Registry Number of 42-O-tert-Butyldimethylsilyloxyethyl Rapamycin is 159351-68-5. It is also known as 40-O-(2-(t-butyldimethylsilyl)oxy)ethyl-rapamycin, 40-O-[2-(t-butyldimethylsilyl)oxy]ethyl-rapamycin, Rapamycin 42-[2-(tert-butyldimethylsilyloxy)ethyl] ether.

What is the molecular formula and molecular weight of 42-O-tert-Butyldimethylsilyloxyethyl Rapamycin?

42-O-tert-Butyldimethylsilyloxyethyl Rapamycin has the molecular formula C59H97NO14Si and a molecular weight of 1072.5 g/mol.

What is 42-O-tert-Butyldimethylsilyloxyethyl Rapamycin used for?

42-O-tert-Butyldimethylsilyloxyethyl Rapamycin is supplied as a characterised reference material related to Everolimus. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 42-O-tert-Butyldimethylsilyloxyethyl Rapamycin can I order?

We supply 42-O-tert-Butyldimethylsilyloxyethyl Rapamycin in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 42-O-tert-Butyldimethylsilyloxyethyl Rapamycin?

Yes. Every lot of 42-O-tert-Butyldimethylsilyloxyethyl Rapamycin is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 42-O-tert-Butyldimethylsilyloxyethyl Rapamycin be shipped internationally?

Yes. 42-O-tert-Butyldimethylsilyloxyethyl Rapamycin is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.