4,4'-Difluorobiphenyl

Name: 4,4'-Difluorobiphenyl
Brand: Vaqora Chemicals
SKU: VQ-035785

About 4,4'-Difluorobiphenyl

4,4'-Difluorobiphenyl (CAS 398-23-2) is an impurity of Aprepitant offered by Vaqora Chemicals. The compound has the formula C12H8F2, corresponding to a molecular weight of 190.19 g/mol. The IUPAC name is 1-fluoro-4-(4-fluorophenyl)benzene. Common synonyms include 4,4'-Difluoro-1,1'-biphenyl and 4,4'-Difluorodiphenyl.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

Pharmaceutical QC and development laboratories use this impurity standard of Aprepitant to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

We offer 4,4'-Difluorobiphenyl in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Aprepitant

View every impurity, metabolite and intermediate we list for Aprepitant.

Aprepitant impurities

Specifications & identifiers

Chemical identifiers
Product name	4,4'-Difluorobiphenyl
Catalogue No.	VQ-035785
CAS Number	398-23-2
IUPAC name	1-fluoro-4-(4-fluorophenyl)benzene
Molecular formula	C₁₂H₈F₂
Molecular weight	190.19 g/mol
Exact mass	190.0594
Grade	Reference Standard
HSN code	38229090
InChIKey	PZDAAZQDQJGXSW-UHFFFAOYSA-N
SMILES	C1=CC(=CC=C1C2=CC=C(C=C2)F)F
PubChem CID	9811

Physical properties
Physical form	Solid
LogP (XLogP3)	4.5
H-bond donors / acceptors	0 / 2
TPSA	0 Å²
Synonyms	4,4'-Difluoro-1,1'-biphenyl, 4,4'-Difluorodiphenyl, 1,1'-Biphenyl, 4,4'-difluoro-, 4,4-Difluoro-1,1-biphenyl, Biphenyl, 4,4'-difluoro-, 4,4'-Difluoro-1,1'-biphenyl #, 4-fluoro-1-(4-fluorophenyl)benzene, 1,1'-Biphenyl,4,4'-difluoro-, Biphenyl,4'-difluoro-

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 4,4'-Difluorobiphenyl?

The CAS Registry Number of 4,4'-Difluorobiphenyl is 398-23-2. It is also known as 4,4'-Difluoro-1,1'-biphenyl, 4,4'-Difluorodiphenyl, 1,1'-Biphenyl, 4,4'-difluoro-.

What is the molecular formula and molecular weight of 4,4'-Difluorobiphenyl?

4,4'-Difluorobiphenyl has the molecular formula C12H8F2 and a molecular weight of 190.19 g/mol. Its IUPAC name is 1-fluoro-4-(4-fluorophenyl)benzene.

What is 4,4'-Difluorobiphenyl used for?

4,4'-Difluorobiphenyl is supplied as a characterised reference material related to Aprepitant. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 4,4'-Difluorobiphenyl can I order?

We supply 4,4'-Difluorobiphenyl in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 4,4'-Difluorobiphenyl?

Yes. Every lot of 4,4'-Difluorobiphenyl is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 4,4'-Difluorobiphenyl be shipped internationally?

Yes. 4,4'-Difluorobiphenyl is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.