5-O-Demethyl-22,23-dihydro-28-hydroxy-Avermec… 127468-07-9

Name: 5-O-Demethyl-22,23-dihydro-28-hydroxy-Avermectin A1a
Brand: Vaqora Chemicals
SKU: VQ-031348

About 5-O-Demethyl-22,23-dihydro-28-hydroxy-Avermectin A1a

5-O-Demethyl-22,23-dihydro-28-hydroxy-Avermectin A1a (CAS 127468-07-9) is a metabolite or degradation product of Ivermectin offered by Vaqora Chemicals. Formula C48H74O15, molecular weight 891.1 g/mol. Alternative names: 8a-hydroxy-ivermectin B1a.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Handle it with standard laboratory precautions and appropriate personal protective equipment.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Ivermectin, as well as in QC testing and ANDA/DMF documentation. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

We offer 5-O-Demethyl-22,23-dihydro-28-hydroxy-Avermectin A1a in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide. A Safety Data Sheet (SDS) and technical specifications are available on request.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Ivermectin

View every impurity, metabolite and intermediate we list for Ivermectin.

Ivermectin impurities

Specifications & identifiers

Chemical identifiers
Product name	5-O-Demethyl-22,23-dihydro-28-hydroxy-Avermectin A1a
Catalogue No.	VQ-031348
CAS Number	127468-07-9
IUPAC name	(1R,4S,5'S,6R,6'R,8R,10Z,12S,13S,14Z,20R,21R,24S)-6'-[(2S)-butan-2-yl]-18,21,24-trihydroxy-12-[(2R,4S,5S,6S)-5-[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-5',11,13,22-tetramethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one
Molecular formula	C₄₈H₇₄O₁₅
Molecular weight	891.1 g/mol
Exact mass	890.5028
Grade	Reference Standard
HSN code	38229090
InChIKey	RLNMDGFQWNQJFT-HATZWMPFSA-N
SMILES	CC[C@H](C)[C@@H]1[C@H](CC[C@@]2(O1)C[C@@H]3C[C@H](O2)C/C=C(\[C@H]([C@H](/C=C\C=C4C(O[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O[C@H]7C[C@@H]([C@H]([C@@H](O7)C)O)OC)OC)/C)C
PubChem CID	154728654

Physical properties
Physical form	Solid
LogP (XLogP3)	3.6
H-bond donors / acceptors	4 / 15
TPSA	190 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 5-O-Demethyl-22,23-dihydro-28-hydroxy-Avermectin A1a?

The CAS Registry Number of 5-O-Demethyl-22,23-dihydro-28-hydroxy-Avermectin A1a is 127468-07-9. It is also known as 8a-hydroxy-ivermectin B1a.

What is the molecular formula and molecular weight of 5-O-Demethyl-22,23-dihydro-28-hydroxy-Avermectin A1a?

5-O-Demethyl-22,23-dihydro-28-hydroxy-Avermectin A1a has the molecular formula C48H74O15 and a molecular weight of 891.1 g/mol.

What is 5-O-Demethyl-22,23-dihydro-28-hydroxy-Avermectin A1a used for?

5-O-Demethyl-22,23-dihydro-28-hydroxy-Avermectin A1a is supplied as a characterised reference material related to Ivermectin. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 5-O-Demethyl-22,23-dihydro-28-hydroxy-Avermectin A1a can I order?

We supply 5-O-Demethyl-22,23-dihydro-28-hydroxy-Avermectin A1a in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 5-O-Demethyl-22,23-dihydro-28-hydroxy-Avermectin A1a?

Yes. Every lot of 5-O-Demethyl-22,23-dihydro-28-hydroxy-Avermectin A1a is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 5-O-Demethyl-22,23-dihydro-28-hydroxy-Avermectin A1a be shipped internationally?

Yes. We export 5-O-Demethyl-22,23-dihydro-28-hydroxy-Avermectin A1a worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.