6-Chloro-2(1H)-pyrimidinone

Name: 6-Chloro-2(1H)-pyrimidinone
Brand: Vaqora Chemicals
SKU: VQ-013154

About 6-Chloro-2(1H)-pyrimidinone

Listed under CAS 80927-55-5, 6-Chloro-2(1H)-pyrimidinone is a process intermediate or related compound of Pazopanib available from Vaqora Chemicals at a purity of 90.91%. With the molecular formula C4H3ClN2O, it has a molar mass of 130.53 g/mol. Its systematic (IUPAC) name is 6-chloro-1H-pyrimidin-2-one. Alternative names: 4-Chloropyrimidin-2(1H)-one and 6-Chloropyrimidin-2(1H)-one.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

Process chemists and analysts use it when developing synthetic routes to Pazopanib, tracking process-related impurities and validating analytical methods. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide. Stock is available for quick dispatch.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development

Industries

Related to Pazopanib

View every impurity, metabolite and intermediate we list for Pazopanib.

Pazopanib impurities

Specifications & identifiers

Chemical identifiers
Product name	6-Chloro-2(1H)-pyrimidinone
Catalogue No.	VQ-013154
CAS Number	80927-55-5
IUPAC name	6-chloro-1H-pyrimidin-2-one
Molecular formula	C₄H₃ClN₂O
Molecular weight	130.53 g/mol
Exact mass	129.9934
Grade	Reference Standard
Purity / assay	90.91%
HSN code	2933
InChIKey	KVHNGYWHLLJFNQ-UHFFFAOYSA-N
SMILES	C1=C(NC(=O)N=C1)Cl
PubChem CID	13244894

Physical properties
Physical form	Solid
LogP (XLogP3)	-1
H-bond donors / acceptors	1 / 1
TPSA	41.5 Å²
Synonyms	4-Chloropyrimidin-2(1H)-one, 6-Chloropyrimidin-2(1H)-one, 4-Chloro-pyrimidin-2-ol, chloropyrimidone, 2(1H)-Pyrimidinone, 4-chloro- (6CI,9CI), 4-chloropyrimidone, chlorohydroxypyrimidine, 2(1H)-Pyrimidinone, 6-chloro-, 4-chloropyrimidin-2(1, 4-Chloro-2-pyrimidinol, 2(1H)-Pyrimidinone, 4-chloro-, 6-Chloropyrimidin-2(1H)-one.xhydrate

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 6-Chloro-2(1H)-pyrimidinone?

The CAS Registry Number of 6-Chloro-2(1H)-pyrimidinone is 80927-55-5. It is also known as 4-Chloropyrimidin-2(1H)-one, 6-Chloropyrimidin-2(1H)-one, 4-Chloro-pyrimidin-2-ol.

What is the molecular formula and molecular weight of 6-Chloro-2(1H)-pyrimidinone?

6-Chloro-2(1H)-pyrimidinone has the molecular formula C4H3ClN2O and a molecular weight of 130.53 g/mol. Its IUPAC name is 6-chloro-1H-pyrimidin-2-one.

What is 6-Chloro-2(1H)-pyrimidinone used for?

6-Chloro-2(1H)-pyrimidinone is supplied as a characterised reference material related to Pazopanib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 6-Chloro-2(1H)-pyrimidinone can I order?

We supply 6-Chloro-2(1H)-pyrimidinone in Reference Standard (90.91%) grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 6-Chloro-2(1H)-pyrimidinone?

Yes. Every lot of 6-Chloro-2(1H)-pyrimidinone is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 6-Chloro-2(1H)-pyrimidinone be shipped internationally?

Yes. 6-Chloro-2(1H)-pyrimidinone is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.