8-Hydroxy Loxapine

Name: 8-Hydroxy Loxapine
Brand: Vaqora Chemicals
SKU: VQ-038168

About 8-Hydroxy Loxapine

8-Hydroxy Loxapine (CAS 61443-77-4) is a metabolite or degradation product of Loxapine offered by Vaqora Chemicals. Its molecular formula is C18H18ClN3O2 and its molecular weight is 343.8 g/mol. Its systematic (IUPAC) name is 8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepin-3-ol.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Loxapine, as well as in QC testing and ANDA/DMF documentation. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies 8-Hydroxy Loxapine in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Loxapine

View every impurity, metabolite and intermediate we list for Loxapine.

Loxapine impurities

Specifications & identifiers

Chemical identifiers
Product name	8-Hydroxy Loxapine
Catalogue No.	VQ-038168
CAS Number	61443-77-4
IUPAC name	8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepin-3-ol
Molecular formula	C₁₈H₁₈ClN₃O₂
Molecular weight	343.8 g/mol
Exact mass	343.1088
Grade	Reference Standard
HSN code	38229090
InChIKey	VNJRIWXLPIYFGI-UHFFFAOYSA-N
SMILES	CN1CCN(CC1)C2=NC3=C(C=CC(=C3)O)OC4=C2C=C(C=C4)Cl
PubChem CID	43655

Physical properties
Physical form	Solid
LogP (XLogP3)	2.7
H-bond donors / acceptors	1 / 4
TPSA	48.3 Å²
Synonyms	Dibenz(b,f)(1,4)oxazepin-8-ol, 2-chloro-11-(4-methyl-1-piperazinyl)-, Dibenz[b,f][1,4]oxazepin-8-ol, 2-chloro-11-(4-methyl-1-piperazinyl)-, 2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepin-8-ol, 2-Chloro-11-(4-methyl-1-piperazinyl)dibenzo[b,f][1,4]oxazepin-8-ol #, 2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]oxazepin-8-ol

Safety & hazard information (GHS)

Toxic

Signal word: Danger

Hazard statements

H301Toxic if swallowed

Precautionary statements: P264, P270, P301 + P316, P321, P330, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 8-Hydroxy Loxapine?

The CAS Registry Number of 8-Hydroxy Loxapine is 61443-77-4. It is also known as Dibenz(b,f)(1,4)oxazepin-8-ol, 2-chloro-11-(4-methyl-1-piperazinyl)-, Dibenz[b,f][1,4]oxazepin-8-ol, 2-chloro-11-(4-methyl-1-piperazinyl)-, 2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepin-8-ol.

What is the molecular formula and molecular weight of 8-Hydroxy Loxapine?

8-Hydroxy Loxapine has the molecular formula C18H18ClN3O2 and a molecular weight of 343.8 g/mol. Its IUPAC name is 8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepin-3-ol.

What is 8-Hydroxy Loxapine used for?

8-Hydroxy Loxapine is supplied as a characterised reference material related to Loxapine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 8-Hydroxy Loxapine can I order?

We supply 8-Hydroxy Loxapine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 8-Hydroxy Loxapine?

Yes. Every lot of 8-Hydroxy Loxapine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 8-Hydroxy Loxapine be shipped internationally?

Yes. 8-Hydroxy Loxapine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.