Afatinib Dimer impurity

Name: Afatinib Dimer impurity
Brand: Vaqora Chemicals
SKU: VQ-021451

About Afatinib Dimer impurity

Afatinib Dimer impurity (CAS 2223677-65-2) is an impurity of Afatinib offered by Vaqora Chemicals. With the molecular formula C38H30Cl2F2N8O6, it has a molar mass of 803.6 g/mol. The IUPAC name is N,N'-bis[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]oxamide. Alternative names: Afatinib Oxalamide Dimer Impurity and Afatinib Impurity 42.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Handle it with standard laboratory precautions and appropriate personal protective equipment.

This Afatinib impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. It is used across pharmaceutical manufacturing and academic and industrial research.

We offer Afatinib Dimer impurity in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Afatinib

View every impurity, metabolite and intermediate we list for Afatinib.

Afatinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Afatinib Dimer impurity
Catalogue No.	VQ-021451
CAS Number	2223677-65-2
IUPAC name	N,N'-bis[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]oxamide
Molecular formula	C₃₈H₃₀Cl₂F₂N₈O₆
Molecular weight	803.6 g/mol
Exact mass	802.1633
Grade	Reference Standard
HSN code	38229090
InChIKey	NMHSIKFQDIYZSG-VXKWHMMOSA-N
SMILES	C1COC[C@H]1OC2=C(C=C3C(=C2)N=CN=C3NC4=CC(=C(C=C4)F)Cl)NC(=O)C(=O)NC5=C(C=C6C(=C5)C(=NC=N6)NC7=CC(=C(C=C7)F)Cl)O[C@H]8CCOC8
PubChem CID	163197463

Physical properties
Physical form	Solid
LogP (XLogP3)	6.9
H-bond donors / acceptors	4 / 14
TPSA	171 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Afatinib Dimer impurity?

The CAS Registry Number of Afatinib Dimer impurity is 2223677-65-2. It is also known as Afatinib Oxalamide Dimer Impurity, Afatinib Impurity 42.

What is the molecular formula and molecular weight of Afatinib Dimer impurity?

Afatinib Dimer impurity has the molecular formula C38H30Cl2F2N8O6 and a molecular weight of 803.6 g/mol. Its IUPAC name is N,N'-bis[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]oxamide.

What is Afatinib Dimer impurity used for?

Afatinib Dimer impurity is supplied as a characterised reference material related to Afatinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Afatinib Dimer impurity can I order?

We supply Afatinib Dimer impurity in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Afatinib Dimer impurity?

Yes. Every lot of Afatinib Dimer impurity is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Afatinib Dimer impurity be shipped internationally?

Yes. We export Afatinib Dimer impurity worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.