Impurity reference standards
Afatinib impurities & reference standards
Characterised Afatinib impurities, degradation products and related compounds for analytical method development, validation, QC release and regulatory filings.
49reference materials
1isotope-labelled
COAHPLC · NMR · MS on request
(E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide
- CAS
- 2085843-51-0
- Formula
- C22H23ClFN5O2
- MW
- 443.9 g/mol
VQ-024156
(E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide
- CAS
- 1245555-42-3
- Formula
- C21H21ClFN5O2
- MW
- 429.9 g/mol
VQ-034775
(R)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine
- CAS
- 402855-07-6
- Formula
- C18H14ClFN4O4
- MW
- 404.8 g/mol
VQ-028904
(R)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((R)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)-3-hydroxybutanamide
- CAS
- 2413212-23-2
- Formula
- C24H27ClFN5O4
- MW
- 504 g/mol
VQ-044037
(S,E)-4-(Dimethylamino)-N-(4-((4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide
- CAS
- 2413212-25-4
- Formula
- C24H26FN5O3
- MW
- 451.5 g/mol
VQ-028798
(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(methylamino)but-2-enamide
- CAS
- 2413212-13-0
- Formula
- C23H23ClFN5O3
- MW
- 471.9 g/mol
VQ-034774
(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-hydroxybut-2-enamide
- CAS
- 2121530-37-6
- Formula
- C22H20ClFN4O4
- MW
- 458.9 g/mol
VQ-021446
(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide
- CAS
- 2223677-64-1
- Formula
- C22H20ClFN4O3
- MW
- 442.9 g/mol
VQ-021447
(S,E)-N-(4-((3,4-Dichlorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
- CAS
- 2223677-63-0
- Formula
- C24H25Cl2N5O3
- MW
- 502.4 g/mol
VQ-021452
(S,E)-N-(4-((3,4-Difluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
- CAS
- 2223677-62-9
- Formula
- C24H25F2N5O3
- MW
- 469.5 g/mol
VQ-021453
(S,Z)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
- CAS
- 1680184-59-1
- Formula
- C24H25ClFN5O3
- MW
- 485.9 g/mol
VQ-021443
(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine
- CAS
- 314771-88-5
- Formula
- C18H14ClFN4O4
- MW
- 404.8 g/mol
VQ-020751
(S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((R)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)-3-hydroxybutanamide
- CAS
- 2413212-21-0
- Formula
- C24H27ClFN5O4
- MW
- 503.95 g/mol
VQ-024154
(S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-3-enamide
- CAS
- 2413212-17-4
- Formula
- C22H20ClFN4O3
- MW
- 442.87 g/mol
VQ-020746
(S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)formamide
- CAS
- 2223677-60-7
- Formula
- C19H16ClFN4O3
- MW
- 402.8 g/mol
VQ-020752
(S)-N4-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy) quinazoline-4,6-diamine
- CAS
- 314771-76-1
- Formula
- C18H16ClFN4O2
- MW
- 374.8 g/mol
VQ-020748
(S)-N4-(3-chlorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
- CAS
- 2413212-09-4
- Formula
- C18H17ClN4O2
- MW
- 356.8 g/mol
VQ-021445
(S)-N4-(3,4-Difluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
- CAS
- 2044709-72-8
- Formula
- C18H16F2N4O2
- MW
- 358.3 g/mol
VQ-028905
(S)-N4-(4-Fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
- CAS
- 2413212-07-2
- Formula
- C18H17FN4O2
- MW
- 340.4 g/mol
VQ-028797
(S)-N4-phenyl-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
- CAS
- 2413212-08-3
- Formula
- C18H18N4O2
- MW
- 322.36 g/mol
VQ-034773
1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one
- CAS
- 2223677-58-3
- Formula
- C22H20ClFN4O4
- MW
- 458.9 g/mol
VQ-020747
![4-N-(3-Chloro-4-fluorophenyl)-7-[(3R)-oxolan-3-yl]oxyquinazoline-4,6-diamine chemical structure](/media/structures/BIQABKFYKJRXII-LLVKDONJSA-N.svg)
4-N-(3-Chloro-4-fluorophenyl)-7-[(3R)-oxolan-3-yl]oxyquinazoline-4,6-diamine
- CAS
- 402855-03-2
- Formula
- C18H16ClFN4O2
- MW
- 374.8 g/mol
VQ-035088
6-Amino-4-((3-chloro-4-fluorophenyl)amino)quinazolin-7-ol
- CAS
- 1449430-53-8
- Formula
- C14H10ClFN4O
- MW
- 304.7 g/mol
VQ-047347
Afatinib Hydroxy-Pyrrolidinonyl (R-Isomer) Impurity
- CAS
- 2413212-19-6
- Formula
- C22H20ClFN4O4
- MW
- 458.87 g/mol
VQ-024159
Ethyl (E)-4-(dimethylamino)but-2-enoate hydrochloride
- CAS
- 1255078-56-8
- Formula
- C8H16ClNO2
- MW
- 193.67 g/mol
VQ-045313
N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine
- CAS
- 179552-74-0
- Formula
- C15H10ClFN4O3
- MW
- 348.71 g/mol
VQ-028799
N-(3,4-Dichlorophenyl)-7-fluoro-6-nitroquinazolin-4-amine
- CAS
- 2512206-82-3
- Formula
- C14H7Cl2FN4O2
- MW
- 353.1 g/mol
VQ-034772
N-(3,4-Difluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine
- CAS
- 2226537-61-5
- Formula
- C14H7F3N4O2
- MW
- 320.23 g/mol
VQ-035634
N-(4-Chloro-3-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine
- CAS
- 2475095-50-0
- Formula
- C14H7ClF2N4O2
- MW
- 336.68 g/mol
VQ-024157
N-(4-Chloro-3-fluorophenyl)-7-fluoro-8-nitroquinazolin-4-amine
- CAS
- 2475094-96-1
- Formula
- C14H7ClF2N4O2
- MW
- 336.68 g/mol
VQ-035252
trans-4-Dimethylaminocrotonic acid hydrochloride
- CAS
- 848133-35-7
- Formula
- C6H12ClNO2
- MW
- 165.62 g/mol
VQ-039380
FAQs — Afatinib impurities
Which Afatinib impurities do you supply?
We list 49 Afatinib-related reference materials, including process impurities, degradation products, stable-isotope-labelled standards and related compounds. Each is supplied with a COA, and characterisation data (HPLC, 1H-NMR, MS, IR) can be provided on request.
What are Afatinib impurity standards used for?
They are used for analytical method development and validation, impurity identification and quantification, forced-degradation and stability studies, and to support ANDA, DMF and other regulatory submissions under ICH Q3A/Q3B (and ICH M7 for mutagenic impurities).
Can you synthesise a Afatinib impurity that is not listed?
Yes. Our custom synthesis service can prepare and characterise unlisted impurities, metabolites and labelled analogues from milligram to gram scale. Share the structure or name and required quantity for a quotation.
Request Afatinib impurity standards
We reply within one business day with price, pack options, lead time and documentation.