Ambrisentan-D10

Name: Ambrisentan-D10
Brand: Vaqora Chemicals
SKU: VQ-035671

About Ambrisentan-D10

Ambrisentan-D10 is a stable isotope labelled analogue related to Ambrisentan carrying the CAS registry number 1046116-27-1. Its molecular formula is C22H22N2O4 and its molecular weight is 388.5 g/mol. Its systematic (IUPAC) name is (2S)-2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-bis(2,3,4,5,6-pentadeuteriophenyl)propanoic acid.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Handle it with standard laboratory precautions and appropriate personal protective equipment.

Its mass shift relative to the unlabelled analyte makes it a dependable internal standard for LC-MS/MS assays, improving accuracy in bioanalysis, therapeutic drug monitoring and method validation. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Ambrisentan-D10 is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

LC-MS/MS internal standard
Bioanalytical quantitation
Pharmacokinetic studies

Industries

Related to Ambrisentan

View every impurity, metabolite and intermediate we list for Ambrisentan.

Ambrisentan impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Ambrisentan-D10
Catalogue No.	VQ-035671
CAS Number	1046116-27-1
IUPAC name	(2S)-2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-bis(2,3,4,5,6-pentadeuteriophenyl)propanoic acid
Molecular formula	C₂₂H₂₂N₂O₄
Molecular weight	388.5 g/mol
Exact mass	388.2207
Grade	Reference Standard
HSN code	38229090
InChIKey	OUJTZYPIHDYQMC-KYBYSFRQSA-N
SMILES	[2H]C1=C(C(=C(C(=C1[2H])[2H])C(C2=C(C(=C(C(=C2[2H])[2H])[2H])[2H])[2H])([C@@H](C(=O)O)OC3=NC(=CC(=N3)C)C)OC)[2H])[2H]
PubChem CID	76973597

Physical properties
Physical form	Solid
LogP (XLogP3)	3.8
H-bond donors / acceptors	1 / 6
TPSA	81.5 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Ambrisentan-D10?

The CAS Registry Number of Ambrisentan-D10 is 1046116-27-1. It is also known as (S)-2-((4,6-dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-bis(phenyl-d5)propanoic acid.

What is the molecular formula and molecular weight of Ambrisentan-D10?

Ambrisentan-D10 has the molecular formula C22H22N2O4 and a molecular weight of 388.5 g/mol. Its IUPAC name is (2S)-2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-bis(2,3,4,5,6-pentadeuteriophenyl)propanoic acid.

What is Ambrisentan-D10 used for?

Ambrisentan-D10 is supplied as a characterised reference material related to Ambrisentan. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Ambrisentan-D10 can I order?

We supply Ambrisentan-D10 in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Ambrisentan-D10?

Yes. Every lot of Ambrisentan-D10 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Ambrisentan-D10 be shipped internationally?

Yes. We export Ambrisentan-D10 worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.