Cladribine

Name: Cladribine
Brand: Vaqora Chemicals
SKU: VQ-022205

About Cladribine

Cladribine is a high-purity reference standard of Cladribine carrying the CAS registry number 4291-63-8. With the molecular formula C10H12ClN5O3, it has a molar mass of 285.69 g/mol. The IUPAC name is (2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol. It is also known as 2-Chloro-2'-deoxyadenosine or Leustatin.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

Laboratories use this Cladribine standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Cladribine

View every impurity, metabolite and intermediate we list for Cladribine.

Cladribine impurities

Specifications & identifiers

Chemical identifiers
Product name	Cladribine
Catalogue No.	VQ-022205
CAS Number	4291-63-8
IUPAC name	(2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
Molecular formula	C₁₀H₁₂ClN₅O₃
Molecular weight	285.69 g/mol
Exact mass	285.0629
Grade	Reference Standard
HSN code	38229090
InChIKey	PTOAARAWEBMLNO-KVQBGUIXSA-N
SMILES	C1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=C(N=C32)Cl)N)CO)O
PubChem CID	20279

Physical properties
Physical form	Solid
LogP (XLogP3)	0.8
H-bond donors / acceptors	3 / 7
TPSA	119 Å²
Synonyms	2-Chloro-2'-deoxyadenosine, Leustatin, 2-Chlorodeoxyadenosine, 2-CdA, Chlorodeoxyadenosine, 2-Chloro-2'-deoxy-beta-adenosine, Cladaribine, 2-chloro-deoxyadenosine, 2ClAdo, 2-chloro-6-amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl)purine, 2-Chloro-6-amino-9-(2-deoxy-beta-D-erythropentofuranosyl)purine, (2R,3S,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-2-(hydroxymethyl)oxolan-3-ol

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Signal word: Danger

Hazard statements

H301+H311+H331Toxic if swallowed, in contact with skin or if inhaled
H301Toxic if swallowed
H311Toxic in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation

Precautionary statements: P261, P262, P264, P264 + P265, P270, P271, P280, P301 + P316, P302 + P352, P304 + P340, P305 + P351 + P338, P316, P319, P321, P330, P332 + P317, P337 + P317, P361 + P364, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Cladribine?

The CAS Registry Number of Cladribine is 4291-63-8. It is also known as 2-Chloro-2'-deoxyadenosine, Leustatin, 2-Chlorodeoxyadenosine.

What is the molecular formula and molecular weight of Cladribine?

Cladribine has the molecular formula C10H12ClN5O3 and a molecular weight of 285.69 g/mol. Its IUPAC name is (2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol.

What is Cladribine used for?

Cladribine is supplied as a characterised reference material related to Cladribine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Cladribine can I order?

We supply Cladribine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Cladribine?

Yes. Every lot of Cladribine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Cladribine be shipped internationally?

Yes. Cladribine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.