Cortisone Acetate

Name: Cortisone Acetate
Brand: Vaqora Chemicals
SKU: VQ-025085

About Cortisone Acetate

Cortisone Acetate (CAS 50-04-4) is an impurity of Hydrocortisone offered by Vaqora Chemicals. Its molecular formula is C23H30O6 and its molecular weight is 402.5 g/mol. Common synonyms include Cortisone 21-Acetate and Cortone acetate.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Pharmaceutical QC and development laboratories use this impurity standard of Hydrocortisone to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Cortisone Acetate is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Hydrocortisone

View every impurity, metabolite and intermediate we list for Hydrocortisone.

Hydrocortisone impurities

Specifications & identifiers

Chemical identifiers
Product name	Cortisone Acetate
Catalogue No.	VQ-025085
CAS Number	50-04-4
IUPAC name	[2-[(8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
Molecular formula	C₂₃H₃₀O₆
Molecular weight	402.5 g/mol
Exact mass	402.2042
Grade	Reference Standard
HSN code	38229090
InChIKey	ITRJWOMZKQRYTA-RFZYENFJSA-N
SMILES	CC(=O)OCC(=O)[C@]1(CC[C@@H]2[C@@]1(CC(=O)[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C)O
PubChem CID	5745

Physical properties
Physical form	Solid
LogP (XLogP3)	2.1
H-bond donors / acceptors	1 / 6
TPSA	97.7 Å²
Synonyms	Cortisone 21-Acetate, Cortone acetate, Cortisyl, Pregn-4-ene-3,11,20-trione, 21-(acetyloxy)-17-hydroxy-, Cortisone, 21-acetate, Cortisone aceticum, 17,21-Dihydroxypregn-4-ene-3,11,20-trione 21-acetate, 21-(Acetyloxy)-17-hydroxypregn-4-ene-3,11,20-trione, 17alpha,21-dihydroxypregn-4-ene-3,11,20-trione acetate, 17-Hydroxy-3,11,20-trioxopregn-4-en-21-yl acetate, 6alpha,9Difluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate 17-Butyrate, Cortate

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Warning

Hazard statements

H312Harmful in contact with skin
H332Harmful if inhaled
H361Suspected of damaging fertility or the unborn child

Precautionary statements: P203, P261, P271, P280, P302 + P352, P304 + P340, P317, P318, P321, P362 + P364, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Cortisone Acetate?

The CAS Registry Number of Cortisone Acetate is 50-04-4. It is also known as Cortisone 21-Acetate, Cortone acetate, Cortisyl.

What is the molecular formula and molecular weight of Cortisone Acetate?

Cortisone Acetate has the molecular formula C23H30O6 and a molecular weight of 402.5 g/mol. Its IUPAC name is [2-[(8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate.

What is Cortisone Acetate used for?

Cortisone Acetate is supplied as a characterised reference material related to Hydrocortisone. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Cortisone Acetate can I order?

We supply Cortisone Acetate in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Cortisone Acetate?

Yes. Every lot of Cortisone Acetate is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Cortisone Acetate be shipped internationally?

Yes. Cortisone Acetate is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.