Dacomitinib Desmethyl Impurity

Name: Dacomitinib Desmethyl Impurity
Brand: Vaqora Chemicals
SKU: VQ-007125

About Dacomitinib Desmethyl Impurity

Vaqora Chemicals supplies Dacomitinib Desmethyl Impurity, a metabolite or degradation product of Dacomitinib registered under CAS number 2468202-15-3 at a purity of 50%. With the molecular formula C23H23ClFN5O2, it has a molar mass of 455.9 g/mol. The IUPAC name is (E)-N-[4-(3-chloro-4-fluoroanilino)-7-hydroxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide. Alternative names: O-Desmethyl Dacomitinib and Dacomitinib Impurity 14.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Good laboratory practice and suitable PPE are recommended during handling.

Analytical teams use this compound to identify metabolites and degradants of Dacomitinib, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide. Stock is available for quick dispatch.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Dacomitinib

View every impurity, metabolite and intermediate we list for Dacomitinib.

Dacomitinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Dacomitinib Desmethyl Impurity
Catalogue No.	VQ-007125
CAS Number	2468202-15-3
IUPAC name	(E)-N-[4-(3-chloro-4-fluoroanilino)-7-hydroxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide
Molecular formula	C₂₃H₂₃ClFN₅O₂
Molecular weight	455.9 g/mol
Exact mass	455.1524
Grade	Reference Standard
Purity / assay	50%
HSN code	38229090
InChIKey	VFBCTMFFOJGSLU-SNAWJCMRSA-N
SMILES	C1CCN(CC1)C/C=C/C(=O)NC2=C(C=C3C(=C2)C(=NC=N3)NC4=CC(=C(C=C4)F)Cl)O
PubChem CID	136045759

Physical properties
Physical form	Solid
LogP (XLogP3)	4.1
H-bond donors / acceptors	3 / 7
TPSA	90.4 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Dacomitinib Desmethyl Impurity?

The CAS Registry Number of Dacomitinib Desmethyl Impurity is 2468202-15-3. It is also known as O-Desmethyl Dacomitinib, Dacomitinib Impurity 14.

What is the molecular formula and molecular weight of Dacomitinib Desmethyl Impurity?

Dacomitinib Desmethyl Impurity has the molecular formula C23H23ClFN5O2 and a molecular weight of 455.9 g/mol. Its IUPAC name is (E)-N-[4-(3-chloro-4-fluoroanilino)-7-hydroxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide.

What is Dacomitinib Desmethyl Impurity used for?

Dacomitinib Desmethyl Impurity is supplied as a characterised reference material related to Dacomitinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Dacomitinib Desmethyl Impurity can I order?

We supply Dacomitinib Desmethyl Impurity in Reference Standard (50%) grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Dacomitinib Desmethyl Impurity?

Yes. Every lot of Dacomitinib Desmethyl Impurity is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Dacomitinib Desmethyl Impurity be shipped internationally?

Yes. We export Dacomitinib Desmethyl Impurity worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.