Dacomitinib

Name: Dacomitinib
Brand: Vaqora Chemicals
SKU: VQ-007405

About Dacomitinib

Listed under CAS 1110813-31-4, Dacomitinib is a high-purity reference standard of Dacomitinib available from Vaqora Chemicals. Formula C24H25ClFN5O2, molecular weight 469.9 g/mol. The IUPAC name is (E)-N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide. Alternative names: Dacomitinib anhydrous and EGFR Inhibitor PF-00299804.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Handle it with standard laboratory precautions and appropriate personal protective equipment.

Laboratories use this Dacomitinib standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Dacomitinib is dispatched with a Certificate of Analysis (COA) to destinations worldwide. Stock is available for quick dispatch.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Dacomitinib

View every impurity, metabolite and intermediate we list for Dacomitinib.

Dacomitinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Dacomitinib
Catalogue No.	VQ-007405
CAS Number	1110813-31-4
Other CAS	1042385-75-0
IUPAC name	(E)-N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide
Molecular formula	C₂₄H₂₅ClFN₅O₂
Molecular weight	469.9 g/mol
Exact mass	469.1681
Grade	Reference Standard
HSN code	38229090
InChIKey	LVXJQMNHJWSHET-AATRIKPKSA-N
SMILES	COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)NC(=O)/C=C/CN4CCCCC4
PubChem CID	11511120

Physical properties
Physical form	Solid
LogP (XLogP3)	4.4
H-bond donors / acceptors	2 / 7
TPSA	79.4 Å²
Synonyms	Dacomitinib anhydrous, EGFR Inhibitor PF-00299804, Dacomitinib (PF299804, PF299), Dacomitinib (PF299804), Dacomitinib (INN), C24H25ClFN5O2, Dacomitinib (PF-00299804), Dacomitinib (Standard), EX-A030, PF-299804 (Dacomitinib PF-00299804), PF-299804 (Dacomitinib,PF-00299804)?, (E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl]-4-(p

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Dacomitinib?

The CAS Registry Number of Dacomitinib is 1110813-31-4. It is also known as Dacomitinib anhydrous, EGFR Inhibitor PF-00299804, Dacomitinib (PF299804, PF299).

What is the molecular formula and molecular weight of Dacomitinib?

Dacomitinib has the molecular formula C24H25ClFN5O2 and a molecular weight of 469.9 g/mol. Its IUPAC name is (E)-N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide.

What is Dacomitinib used for?

Dacomitinib is supplied as a characterised reference material related to Dacomitinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Dacomitinib can I order?

We supply Dacomitinib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Dacomitinib?

Yes. Every lot of Dacomitinib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Dacomitinib be shipped internationally?

Yes. We export Dacomitinib worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.