Dolutegravir

Name: Dolutegravir
Brand: Vaqora Chemicals
SKU: VQ-022421

About Dolutegravir

Vaqora Chemicals supplies Dolutegravir, a high-purity reference standard of Dolutegravir registered under CAS number 1051375-16-6. Its molecular formula is C20H19F2N3O5 and its molecular weight is 419.4 g/mol. Common synonyms include Dolutegravir (GSK1349572) and Dolutegravir DTG.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

Laboratories use this Dolutegravir standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Dolutegravir in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Dolutegravir

View every impurity, metabolite and intermediate we list for Dolutegravir.

Dolutegravir impurities

Specifications & identifiers

Chemical identifiers
Product name	Dolutegravir
Catalogue No.	VQ-022421
CAS Number	1051375-16-6
IUPAC name	(3S,7R)-N-[(2,4-difluorophenyl)methyl]-11-hydroxy-7-methyl-9,12-dioxo-4-oxa-1,8-diazatricyclo[8.4.0.03,8]tetradeca-10,13-diene-13-carboxamide
Molecular formula	C₂₀H₁₉F₂N₃O₅
Molecular weight	419.4 g/mol
Exact mass	419.1293
Grade	Reference Standard
HSN code	38229090
InChIKey	RHWKPHLQXYSBKR-BMIGLBTASA-N
SMILES	C[C@@H]1CCO[C@@H]2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O
PubChem CID	54726191

Physical properties
Physical form	Solid
LogP (XLogP3)	2.4
H-bond donors / acceptors	2 / 8
TPSA	99.2 Å²
Synonyms	Dolutegravir (GSK1349572), Dolutegravir DTG, Dolutegravir (USAN), 3s3m, 3s3n, 3s3o, EX-A1695

Safety & hazard information (GHS)

Environmental hazard

Signal word: Warning

Hazard statements

H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects

Precautionary statements: P273, P391, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Dolutegravir?

The CAS Registry Number of Dolutegravir is 1051375-16-6. It is also known as Dolutegravir (GSK1349572), Dolutegravir DTG, Dolutegravir (USAN).

What is the molecular formula and molecular weight of Dolutegravir?

Dolutegravir has the molecular formula C20H19F2N3O5 and a molecular weight of 419.4 g/mol. Its IUPAC name is (3S,7R)-N-[(2,4-difluorophenyl)methyl]-11-hydroxy-7-methyl-9,12-dioxo-4-oxa-1,8-diazatricyclo[8.4.0.03,8]tetradeca-10,13-diene-13-carboxamide.

What is Dolutegravir used for?

Dolutegravir is supplied as a characterised reference material related to Dolutegravir. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Dolutegravir can I order?

We supply Dolutegravir in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Dolutegravir?

Yes. Every lot of Dolutegravir is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Dolutegravir be shipped internationally?

Yes. Dolutegravir is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.