![(4R,12AR)-7-Methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid chemical structure](/media/structures/KGWJKKUSXSBPSK-VXNVDRBHSA-N.svg)
(4R,12AR)-7-Methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid
- CAS
- 2315439-81-5
- Formula
- C14H16N2O6
- MW
- 308.29 g/mol
VQ-030263
Impurity reference standards
Dolutegravir impurities & reference standards
Characterised Dolutegravir impurities, degradation products and related compounds for analytical method development, validation, QC release and regulatory filings.
49reference materials
1isotope-labelled
COAHPLC · NMR · MS on request
![(4R,12AS)-N-Benzyl-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide](/media/pack/4r12as-n-benzyl-7-methoxy-4-methyl-68-dioxo-34681212a-hexahydro-2h-pyrido12-45pyrazino21.svg?v=3)
(4R,12AS)-N-Benzyl-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
- CAS
- 2244245-34-7
- Formula
- C21H23N3O5
- MW
- 397.43 g/mol
VQ-036777
![(4S,12AS)-7-Methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic Acid chemical structure](/media/structures/KGWJKKUSXSBPSK-CBAPKCEASA-N.svg)
(4S,12AS)-7-Methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic Acid
- CAS
- 2730133-58-9
- Formula
- C14H16N2O6
- MW
- 308.29 g/mol
VQ-030264
![(R)-2-(4-Hydroxybutan-2-yl)-9-methoxy-1,8-dioxo-1,8-dihydro-2H-pyrido[1,2-a]pyrazine-7-carboxylic Acid chemical structure](/media/structures/XRQILRQQCXIUEI-MRVPVSSYSA-N.svg)
(R)-2-(4-Hydroxybutan-2-yl)-9-methoxy-1,8-dioxo-1,8-dihydro-2H-pyrido[1,2-a]pyrazine-7-carboxylic Acid
- CAS
- 2710626-41-6
- Formula
- C14H16N2O6
- MW
- 308.29 g/mol
VQ-030262
![(R)-N-(2,4-Difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-2,3,4,8-tetrahydro-1H-pyrido[1,2-a]pyrazine-7-carboxamide chemical structure](/media/structures/IODTZUSLUARPHN-LLVKDONJSA-N.svg)
(R)-N-(2,4-Difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-2,3,4,8-tetrahydro-1H-pyrido[1,2-a]pyrazine-7-carboxamide
- CAS
- 2518311-04-9
- Formula
- C20H21F2N3O5
- MW
- 421.4 g/mol
VQ-048068
![(Z)-Methyl2-[(Dimethylamino)methylene]-4-methoxy-3-oxobutanoate chemical structure](/media/structures/YOMXMNVCBBDQDO-UHFFFAOYSA-N.svg)
(Z)-Methyl2-[(Dimethylamino)methylene]-4-methoxy-3-oxobutanoate
- CAS
- 127958-23-0
- Formula
- C9H15NO4
- MW
- 201.22 g/mol
VQ-048065
1-(2,2-Dimethoxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2,5-dicarboxylic Acid
- CAS
- 2651309-06-5
- Formula
- C12H15NO8
- MW
- 301.25 g/mol
VQ-030261
1-(2,2-Dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic Acid
- CAS
- 1335210-23-5
- Formula
- C13H17NO8
- MW
- 315.28 g/mol
VQ-025361
![4-Oxo-3-[(Phenylmethyl)oxy]-4H-pyran-2-carboxylic acid chemical structure](/media/structures/KJSJBKBZMGSIPT-UHFFFAOYSA-N.svg)
4-Oxo-3-[(Phenylmethyl)oxy]-4H-pyran-2-carboxylic acid
- CAS
- 119736-16-2
- Formula
- C13H10O5
- MW
- 246.21 g/mol
VQ-043922
Dimethyl-1-(2,2-dimethoxyethyl)-3-methoxy-4-oxo-1,4-dihydropyridine-2,5-dicarboxylate
- CAS
- 1646862-02-3
- Formula
- C14H19NO8
- MW
- 329.3 g/mol
VQ-036775
![N-[(2,4-Difluorophenyl)methylene]-2,4-difluoro-benzenemethanamine chemical structure](/media/structures/PGPHQWXWIJMODM-UHFFFAOYSA-N.svg)
N-[(2,4-Difluorophenyl)methylene]-2,4-difluoro-benzenemethanamine
- CAS
- 1916490-96-4
- Formula
- C14H9F4N
- MW
- 267.22 g/mol
VQ-030260
FAQs — Dolutegravir impurities
Which Dolutegravir impurities do you supply?
We list 49 Dolutegravir-related reference materials, including process impurities, degradation products, stable-isotope-labelled standards and related compounds. Each is supplied with a COA, and characterisation data (HPLC, 1H-NMR, MS, IR) can be provided on request.
What are Dolutegravir impurity standards used for?
They are used for analytical method development and validation, impurity identification and quantification, forced-degradation and stability studies, and to support ANDA, DMF and other regulatory submissions under ICH Q3A/Q3B (and ICH M7 for mutagenic impurities).
Can you synthesise a Dolutegravir impurity that is not listed?
Yes. Our custom synthesis service can prepare and characterise unlisted impurities, metabolites and labelled analogues from milligram to gram scale. Share the structure or name and required quantity for a quotation.
Request Dolutegravir impurity standards
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