Donepezil

Name: Donepezil
Brand: Vaqora Chemicals
SKU: VQ-007432

About Donepezil

Donepezil (CAS 120014-06-4) is a high-purity reference standard of Donepezil offered by Vaqora Chemicals. Its molecular formula is C24H29NO3 and its molecular weight is 379.5 g/mol. Systematically, it is named 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one. It is also known as (±)-E 2020 or Neuripezil.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

As a reference sample of Donepezil, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Donepezil in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Donepezil

View every impurity, metabolite and intermediate we list for Donepezil.

Donepezil impurities

Specifications & identifiers

Chemical identifiers
Product name	Donepezil
Catalogue No.	VQ-007432
CAS Number	120014-06-4
IUPAC name	2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
Molecular formula	C₂₄H₂₉NO₃
Molecular weight	379.5 g/mol
Exact mass	379.2147
Grade	Reference Standard
HSN code	38229090
InChIKey	ADEBPBSSDYVVLD-UHFFFAOYSA-N
SMILES	COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC
PubChem CID	3152

Physical properties
Physical form	Solid
LogP (XLogP3)	4.3
H-bond donors / acceptors	0 / 4
TPSA	38.8 Å²
Synonyms	,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one, (±)-E 2020, 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine, 2-(1-Benzyl-piperidin-4-ylmethyl)-5,6-dimethoxy-indan-1-one, 2-[(1-Benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one, Neuripezil, Tonizep, 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-, donezpil hydrochloride, 5,6-dimethoxy-2-((1-(phenylmethyl)piperidin-4-yl)methyl)-2,3-dihydroinden-1-one, 5,6-dimethoxy-2-[[1-(phenylmethyl)piperidin-4-yl]methyl]-2,3-dihydroinden-1-one

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Signal word: Danger

Hazard statements

H300Fatal if swallowed
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H413May cause long lasting harmful effects to aquatic life

Precautionary statements: P261, P264, P264 + P265, P270, P271, P273, P280, P301 + P316, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Donepezil?

The CAS Registry Number of Donepezil is 120014-06-4. It is also known as ,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one, (±)-E 2020, 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine.

What is the molecular formula and molecular weight of Donepezil?

Donepezil has the molecular formula C24H29NO3 and a molecular weight of 379.5 g/mol. Its IUPAC name is 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one.

What is Donepezil used for?

Donepezil is supplied as a characterised reference material related to Donepezil. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Donepezil can I order?

We supply Donepezil in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Donepezil?

Yes. Every lot of Donepezil is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Donepezil be shipped internationally?

Yes. Donepezil is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.