Donepezil Dehydro Impurity

Name: Donepezil Dehydro Impurity
Brand: Vaqora Chemicals
SKU: VQ-030279

About Donepezil Dehydro Impurity

Listed under CAS 120014-07-5, Donepezil Dehydro Impurity is an impurity of Donepezil available from Vaqora Chemicals. Its molecular formula is C24H27NO3 and its molecular weight is 377.5 g/mol. The IUPAC name is (2E)-2-[(1-benzylpiperidin-4-yl)methylidene]-5,6-dimethoxy-3H-inden-1-one. Alternative names: Donepezil Dehydro Impurity (E/Z mixture) and Dehydro Donepezil(E/Z mixture).

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

Pharmaceutical QC and development laboratories use this impurity standard of Donepezil to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Donepezil Dehydro Impurity is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Donepezil

View every impurity, metabolite and intermediate we list for Donepezil.

Donepezil impurities

Specifications & identifiers

Chemical identifiers
Product name	Donepezil Dehydro Impurity
Catalogue No.	VQ-030279
CAS Number	120014-07-5
IUPAC name	(2E)-2-[(1-benzylpiperidin-4-yl)methylidene]-5,6-dimethoxy-3H-inden-1-one
Molecular formula	C₂₄H₂₇NO₃
Molecular weight	377.5 g/mol
Exact mass	377.1991
Grade	Reference Standard
HSN code	38229090
InChIKey	LPMOTUSFDTTWJL-UDWIEESQSA-N
SMILES	COC1=C(C=C2C(=C1)C/C(=C\C3CCN(CC3)CC4=CC=CC=C4)/C2=O)OC
PubChem CID	10762160

Physical properties
Physical form	Solid
LogP (XLogP3)	4.2
H-bond donors / acceptors	0 / 4
TPSA	38.8 Å²
Synonyms	Donepezil Dehydro Impurity (E/Z mixture), Dehydro Donepezil(E/Z mixture), (E)-2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxyindan-1-one, 2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxyindan-1-one, (E)-, 2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one, 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine, (E)-2-((1-benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one, (2E)-2-[(1-benzylpiperidin-4-yl)methylidene]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one, (2E)-Dehydrodonepezil, 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methylene]-, (2~{E})-5,6-dimethoxy-2-[[1-(phenylmethyl)piperidin-4-yl]methylidene]-3~{H}-inden-1-one, 2-[(1-Benzyl-4-piperidyl)methylene]-5,6-dimethoxy-1-indanone

Safety & hazard information (GHS)

Toxic

Signal word: Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements: P264, P270, P301 + P316, P321, P330, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Donepezil Dehydro Impurity?

The CAS Registry Number of Donepezil Dehydro Impurity is 120014-07-5. It is also known as Donepezil Dehydro Impurity (E/Z mixture), Dehydro Donepezil(E/Z mixture), (E)-2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxyindan-1-one.

What is the molecular formula and molecular weight of Donepezil Dehydro Impurity?

Donepezil Dehydro Impurity has the molecular formula C24H27NO3 and a molecular weight of 377.5 g/mol. Its IUPAC name is (2E)-2-[(1-benzylpiperidin-4-yl)methylidene]-5,6-dimethoxy-3H-inden-1-one.

What is Donepezil Dehydro Impurity used for?

Donepezil Dehydro Impurity is supplied as a characterised reference material related to Donepezil. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Donepezil Dehydro Impurity can I order?

We supply Donepezil Dehydro Impurity in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Donepezil Dehydro Impurity?

Yes. Every lot of Donepezil Dehydro Impurity is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Donepezil Dehydro Impurity be shipped internationally?

Yes. Donepezil Dehydro Impurity is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.