Donepezil EP Impurity A

Name: Donepezil EP Impurity A
Brand: Vaqora Chemicals
SKU: VQ-022430

About Donepezil EP Impurity A

Donepezil EP Impurity A is a pharmacopeial impurity of Donepezil carrying the CAS registry number 120014-30-4. The compound has the formula C17H23NO3, corresponding to a molecular weight of 289.4 g/mol. Systematically, it is named 5,6-dimethoxy-2-(piperidin-4-ylmethyl)-2,3-dihydroinden-1-one. Common synonyms include Donepezil - Impurity A (Freebase) and Desbenzyl donepezil.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

This Donepezil impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Donepezil EP Impurity A is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Donepezil

View every impurity, metabolite and intermediate we list for Donepezil.

Donepezil impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Donepezil EP Impurity A
Catalogue No.	VQ-022430
CAS Number	120014-30-4
IUPAC name	5,6-dimethoxy-2-(piperidin-4-ylmethyl)-2,3-dihydroinden-1-one
Molecular formula	C₁₇H₂₃NO₃
Molecular weight	289.4 g/mol
Exact mass	289.1678
Grade	Reference Standard
HSN code	38229090
InChIKey	PGBZORAISITZTF-UHFFFAOYSA-N
SMILES	COC1=C(C=C2C(=C1)CC(C2=O)CC3CCNCC3)OC
PubChem CID	10446897

Physical properties
Physical form	Solid
LogP (XLogP3)	2.3
H-bond donors / acceptors	1 / 4
TPSA	47.6 Å²
Synonyms	Donepezil - Impurity A (Freebase), 5,6-Dimethoxy-2-(piperidin-4-ylmethyl)-2,3-dihydro-1H-inden-1-one, Desbenzyl donepezil, 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-(4-piperidinylmethyl)-, 5,6-dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one, 5,6-Dimethoxy-2-((4-piperidyl)methyl)indan-1-one, 5,6-dimethoxy-2-(piperidin-4-ylmethyl)indan-1-one, 5,6-Dimethoxy-2-((4-piperidinyl)methyl)-1-indanone, 4-((5,6-Dimethoxy-1-oxoindan-2-yl)methyl)piperidine, 5,6-dimethoxy-2-[(4-piperidinyl)methyl]-1-indanone, 5,6-Dimethoxy-2-piperidin-4-ylmethyl-indan-1-one, 5,6-dimethoxy-2-(piperidin-4-yl)methylindan-1-one

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation

Precautionary statements: P264, P264 + P265, P280, P302 + P352, P305 + P351 + P338, P321, P332 + P317, P337 + P317, P362 + P364

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Donepezil EP Impurity A?

The CAS Registry Number of Donepezil EP Impurity A is 120014-30-4. It is also known as Donepezil - Impurity A (Freebase), 5,6-Dimethoxy-2-(piperidin-4-ylmethyl)-2,3-dihydro-1H-inden-1-one, Desbenzyl donepezil.

What is the molecular formula and molecular weight of Donepezil EP Impurity A?

Donepezil EP Impurity A has the molecular formula C17H23NO3 and a molecular weight of 289.4 g/mol. Its IUPAC name is 5,6-dimethoxy-2-(piperidin-4-ylmethyl)-2,3-dihydroinden-1-one.

What is Donepezil EP Impurity A used for?

Donepezil EP Impurity A is supplied as a characterised reference material related to Donepezil. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Donepezil EP Impurity A can I order?

We supply Donepezil EP Impurity A in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Donepezil EP Impurity A?

Yes. Every lot of Donepezil EP Impurity A is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Donepezil EP Impurity A be shipped internationally?

Yes. Donepezil EP Impurity A is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.