Elexacaftor

Name: Elexacaftor
Brand: Vaqora Chemicals
SKU: VQ-025509

About Elexacaftor

Listed under CAS 2216712-66-0, Elexacaftor is a high-purity reference standard of Elexacaftor available from Vaqora Chemicals. Formula C26H34F3N7O4S, molecular weight 597.7 g/mol. Alternative names: VX-445 and N-Desmethyl Elexacaftor.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

As a reference sample of Elexacaftor, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Elexacaftor

View every impurity, metabolite and intermediate we list for Elexacaftor.

Elexacaftor impurities

Specifications & identifiers

Chemical identifiers
Product name	Elexacaftor
Catalogue No.	VQ-025509
CAS Number	2216712-66-0
IUPAC name	N-(1,3-dimethylpyrazol-4-yl)sulfonyl-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide
Molecular formula	C₂₆H₃₄F₃N₇O₄S
Molecular weight	597.7 g/mol
Exact mass	597.2345
Grade	Reference Standard
HSN code	38229090
InChIKey	MVRHVFSOIWFBTE-INIZCTEOSA-N
SMILES	C[C@H]1CC(N(C1)C2=C(C=CC(=N2)N3C=CC(=N3)OCC(C)(C)C(F)(F)F)C(=O)NS(=O)(=O)C4=CN(N=C4C)C)(C)C
PubChem CID	134587348

Physical properties
Physical form	Solid
LogP (XLogP3)	4.9
H-bond donors / acceptors	1 / 11
TPSA	133 Å²
Synonyms	VX-445, N-Desmethyl Elexacaftor, Elexacaftor (USAN), Elexacaftor (VX-445), EX-A3637, Compound 1 [WO2018107100A1]

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Elexacaftor?

The CAS Registry Number of Elexacaftor is 2216712-66-0. It is also known as VX-445, N-Desmethyl Elexacaftor, Elexacaftor (USAN).

What is the molecular formula and molecular weight of Elexacaftor?

Elexacaftor has the molecular formula C26H34F3N7O4S and a molecular weight of 597.7 g/mol. Its IUPAC name is N-(1,3-dimethylpyrazol-4-yl)sulfonyl-6-[3-(3,3,3-trifluoro-2,2-dimethylpropoxy)pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide.

What is Elexacaftor used for?

Elexacaftor is supplied as a characterised reference material related to Elexacaftor. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Elexacaftor can I order?

We supply Elexacaftor in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Elexacaftor?

Yes. Every lot of Elexacaftor is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Elexacaftor be shipped internationally?

Yes. Elexacaftor is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.