Estrone-d4

Name: Estrone-d4
Brand: Vaqora Chemicals
SKU: VQ-037133

About Estrone-d4

Listed under CAS 53866-34-5, Estrone-d4 is a stable isotope labelled analogue related to Estrone available from Vaqora Chemicals. The compound has the formula C18H22O2, corresponding to a molecular weight of 274.4 g/mol. Alternative names: Estrone-2,4,16,16-d4 and 1,3,5(10)-Estratrien-3-ol-17-one-d4.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

Its mass shift relative to the unlabelled analyte makes it a dependable internal standard for LC-MS/MS assays, improving accuracy in bioanalysis, therapeutic drug monitoring and method validation. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Estrone-d4 in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

LC-MS/MS internal standard
Bioanalytical quantitation
Pharmacokinetic studies

Industries

Related to Estrone

View every impurity, metabolite and intermediate we list for Estrone.

Estrone impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Estrone-d4
Catalogue No.	VQ-037133
CAS Number	53866-34-5
IUPAC name	(8R,9S,13S,14S)-2,4,16,16-tetradeuterio-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15-octahydrocyclopenta[a]phenanthren-17-one
Molecular formula	C₁₈H₂₂O₂
Molecular weight	274.4 g/mol
Exact mass	274.1871
Grade	Reference Standard
HSN code	38229090
InChIKey	DNXHEGUUPJUMQT-QSPUTOQOSA-N
SMILES	[2H]C1=CC2=C(CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC(C4=O)([2H])[2H])C)C(=C1O)[2H]
PubChem CID	11737421

Physical properties
Physical form	Solid
LogP (XLogP3)	3.1
H-bond donors / acceptors	1 / 2
TPSA	37.3 Å²
Synonyms	Estrone-2,4,16,16-d4, 1,3,5(10)-Estratrien-3-ol-17-one-d4, TMIJ-0255, Estrone D4 (2,4,16,16-D4), 3-Hydroxy(2,4,16,16-~2~H_4_)estra-1,3,5(10)-trien-17-one

Safety & hazard information (GHS)

Health hazard

Signal word: Danger

Hazard statements

H350May cause cancer
H360May damage fertility or the unborn child

Precautionary statements: P203, P280, P318, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Estrone-d4?

The CAS Registry Number of Estrone-d4 is 53866-34-5. It is also known as Estrone-2,4,16,16-d4, 1,3,5(10)-Estratrien-3-ol-17-one-d4, TMIJ-0255.

What is the molecular formula and molecular weight of Estrone-d4?

Estrone-d4 has the molecular formula C18H22O2 and a molecular weight of 274.4 g/mol. Its IUPAC name is (8R,9S,13S,14S)-2,4,16,16-tetradeuterio-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15-octahydrocyclopenta[a]phenanthren-17-one.

What is Estrone-d4 used for?

Estrone-d4 is supplied as a characterised reference material related to Estrone. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Estrone-d4 can I order?

We supply Estrone-d4 in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Estrone-d4?

Yes. Every lot of Estrone-d4 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Estrone-d4 be shipped internationally?

Yes. Estrone-d4 is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.