Fmoc-L-His(2-Oxo)-OH

Name: Fmoc-L-His(2-Oxo)-OH
Brand: Vaqora Chemicals
SKU: VQ-035299

About Fmoc-L-His(2-Oxo)-OH

Fmoc-L-His(2-Oxo)-OH is an impurity of Histidine carrying the CAS registry number 2679858-41-2. With the molecular formula C21H19N3O5, it has a molar mass of 393.4 g/mol. Systematically, it is named (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2-oxo-1,3-dihydroimidazol-4-yl)propanoic acid.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

As a characterised impurity of Histidine, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Fmoc-L-His(2-Oxo)-OH is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Histidine

View every impurity, metabolite and intermediate we list for Histidine.

Histidine impurities

Specifications & identifiers

Chemical identifiers
Product name	Fmoc-L-His(2-Oxo)-OH
Catalogue No.	VQ-035299
CAS Number	2679858-41-2
IUPAC name	(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2-oxo-1,3-dihydroimidazol-4-yl)propanoic acid
Molecular formula	C₂₁H₁₉N₃O₅
Molecular weight	393.4 g/mol
Exact mass	393.1325
Grade	Reference Standard
HSN code	38229090
InChIKey	AILXKCISCBPYOZ-SFHVURJKSA-N
SMILES	C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)N[C@@H](CC4=CNC(=O)N4)C(=O)O
PubChem CID	165908115

Physical properties
Physical form	Solid
LogP (XLogP3)	1.9
H-bond donors / acceptors	4 / 5
TPSA	117 Å²

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Fmoc-L-His(2-Oxo)-OH?

The CAS Registry Number of Fmoc-L-His(2-Oxo)-OH is 2679858-41-2. It is also known as (S)-2-(Fmoc-amino)-3-(2-oxo-2,3-dihydro-4-imidazolyl)propanoic Acid.

What is the molecular formula and molecular weight of Fmoc-L-His(2-Oxo)-OH?

Fmoc-L-His(2-Oxo)-OH has the molecular formula C21H19N3O5 and a molecular weight of 393.4 g/mol. Its IUPAC name is (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2-oxo-1,3-dihydroimidazol-4-yl)propanoic acid.

What is Fmoc-L-His(2-Oxo)-OH used for?

Fmoc-L-His(2-Oxo)-OH is supplied as a characterised reference material related to Histidine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Fmoc-L-His(2-Oxo)-OH can I order?

We supply Fmoc-L-His(2-Oxo)-OH in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Fmoc-L-His(2-Oxo)-OH?

Yes. Every lot of Fmoc-L-His(2-Oxo)-OH is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Fmoc-L-His(2-Oxo)-OH be shipped internationally?

Yes. Fmoc-L-His(2-Oxo)-OH is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.