1-Nitroso-L-histidine

Name: 1-Nitroso-L-histidine
Brand: Vaqora Chemicals
SKU: VQ-044811

About 1-Nitroso-L-histidine

1-Nitroso-L-histidine (CAS 932446-62-3) is a nitrosamine impurity of Histidine offered by Vaqora Chemicals. Formula C6H8N4O3, molecular weight 184.15 g/mol. Its systematic (IUPAC) name is (2S)-2-amino-3-(1-nitrosoimidazol-4-yl)propanoic acid. It is also known as N-nitroso-L-histidine or Nt-nitroso-L-histidine.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Handle it with standard laboratory precautions and appropriate personal protective equipment.

Laboratories use this nitrosamine standard to develop and validate highly sensitive LC-MS/MS methods, to confirm limits of detection and to document nitrosamine risk assessments in regulatory submissions. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

We offer 1-Nitroso-L-histidine in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Histidine

View every impurity, metabolite and intermediate we list for Histidine.

Histidine impurities

Specifications & identifiers

Chemical identifiers
Product name	1-Nitroso-L-histidine
Catalogue No.	VQ-044811
CAS Number	932446-62-3
IUPAC name	(2S)-2-amino-3-(1-nitrosoimidazol-4-yl)propanoic acid
Molecular formula	C₆H₈N₄O₃
Molecular weight	184.15 g/mol
Exact mass	184.0596
Grade	Reference Standard
HSN code	38229090
InChIKey	XSIZTDBKCFQKGP-YFKPBYRVSA-N
SMILES	C1=C(N=CN1N=O)C[C@@H](C(=O)O)N
PubChem CID	176472920

Physical properties
Physical form	Solid
LogP (XLogP3)	-3.5
H-bond donors / acceptors	2 / 6
TPSA	111 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 1-Nitroso-L-histidine?

The CAS Registry Number of 1-Nitroso-L-histidine is 932446-62-3. It is also known as N-nitroso-L-histidine, Nt-nitroso-L-histidine.

What is the molecular formula and molecular weight of 1-Nitroso-L-histidine?

1-Nitroso-L-histidine has the molecular formula C6H8N4O3 and a molecular weight of 184.15 g/mol. Its IUPAC name is (2S)-2-amino-3-(1-nitrosoimidazol-4-yl)propanoic acid.

What is 1-Nitroso-L-histidine used for?

1-Nitroso-L-histidine is supplied as a characterised reference material related to Histidine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 1-Nitroso-L-histidine can I order?

We supply 1-Nitroso-L-histidine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 1-Nitroso-L-histidine?

Yes. Every lot of 1-Nitroso-L-histidine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 1-Nitroso-L-histidine be shipped internationally?

Yes. We export 1-Nitroso-L-histidine worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.