Ivacaftor Malonate Impurity

Name: Ivacaftor Malonate Impurity
Brand: Vaqora Chemicals
SKU: VQ-031340

About Ivacaftor Malonate Impurity

Vaqora Chemicals supplies Ivacaftor Malonate Impurity, an impurity of Ivacaftor registered under CAS number 54535-22-7. The compound has the formula C14H17NO4, corresponding to a molecular weight of 263.29 g/mol. The IUPAC name is diethyl 2-(anilinomethylidene)propanedioate. It is also known as Diethyl 2-((phenylamino)methylene)malonate or Diethyl 2-(anilinomethylene)malonate.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Pharmaceutical QC and development laboratories use this impurity standard of Ivacaftor to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Ivacaftor Malonate Impurity is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Ivacaftor

View every impurity, metabolite and intermediate we list for Ivacaftor.

Ivacaftor impurities

Specifications & identifiers

Chemical identifiers
Product name	Ivacaftor Malonate Impurity
Catalogue No.	VQ-031340
CAS Number	54535-22-7
IUPAC name	diethyl 2-(anilinomethylidene)propanedioate
Molecular formula	C₁₄H₁₇NO₄
Molecular weight	263.29 g/mol
Exact mass	263.1158
Grade	Reference Standard
HSN code	38229090
InChIKey	PYPCDUKQEIPHAF-UHFFFAOYSA-N
SMILES	CCOC(=O)C(=CNC1=CC=CC=C1)C(=O)OCC
PubChem CID	264327

Physical properties
Physical form	Solid
LogP (XLogP3)	3.2
H-bond donors / acceptors	1 / 5
TPSA	64.6 Å²
Synonyms	2-phenylaminomethylene-malonic acid diethyl ester, Diethyl 2-((phenylamino)methylene)malonate, Diethyl 2-(anilinomethylene)malonate, Diethyl anilinomethylenemalonate, diethyl 2-(anilinomethylene)propanedioate, 1,3-diethyl 2-[(phenylamino)methylidene]propanedioate, Diethyl 2-[(Phenylamino)methylene]malonate, diethyl (anilinomethylene)malonate, Diethyl2-((phenylamino)methylene)malonate, Propanedioic acid, [(phenylamino)methylene]-, diethyl ester, Diethyl 2-(anilinomethylene)malonate #, Diethyl (anilinomethylidene)propanedioate

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Ivacaftor Malonate Impurity?

The CAS Registry Number of Ivacaftor Malonate Impurity is 54535-22-7. It is also known as 2-phenylaminomethylene-malonic acid diethyl ester, Diethyl 2-((phenylamino)methylene)malonate, Diethyl 2-(anilinomethylene)malonate.

What is the molecular formula and molecular weight of Ivacaftor Malonate Impurity?

Ivacaftor Malonate Impurity has the molecular formula C14H17NO4 and a molecular weight of 263.29 g/mol. Its IUPAC name is diethyl 2-(anilinomethylidene)propanedioate.

What is Ivacaftor Malonate Impurity used for?

Ivacaftor Malonate Impurity is supplied as a characterised reference material related to Ivacaftor. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Ivacaftor Malonate Impurity can I order?

We supply Ivacaftor Malonate Impurity in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Ivacaftor Malonate Impurity?

Yes. Every lot of Ivacaftor Malonate Impurity is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Ivacaftor Malonate Impurity be shipped internationally?

Yes. Ivacaftor Malonate Impurity is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.