Levothyroxine Impurity D (Stage-6)

Name: Levothyroxine Impurity D (Stage-6)
Brand: Vaqora Chemicals
SKU: VQ-005192

About Levothyroxine Impurity D (Stage-6)

Levothyroxine Impurity D (Stage-6) (CAS 1155-40-4) is an impurity of Levothyroxine offered by Vaqora Chemicals. With the molecular formula C14H10I2O4, it has a molar mass of 496.03 g/mol. The IUPAC name is 2-[4-(4-hydroxyphenoxy)-3,5-diiodophenyl]acetic acid. It is also known as 3,5-Diiodothyroacetic acid or Diac.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

As a characterised impurity of Levothyroxine, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Levothyroxine Impurity D (Stage-6) in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide. Stock is available for quick dispatch.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Levothyroxine

View every impurity, metabolite and intermediate we list for Levothyroxine.

Levothyroxine impurities

Specifications & identifiers

Chemical identifiers
Product name	Levothyroxine Impurity D (Stage-6)
Catalogue No.	VQ-005192
CAS Number	1155-40-4
IUPAC name	2-[4-(4-hydroxyphenoxy)-3,5-diiodophenyl]acetic acid
Molecular formula	C₁₄H₁₀I₂O₄
Molecular weight	496.03 g/mol
Exact mass	495.8668
Grade	Reference Standard
HSN code	38229090
InChIKey	KKJBNMLZBHFYAE-UHFFFAOYSA-N
SMILES	C1=CC(=CC=C1O)OC2=C(C=C(C=C2I)CC(=O)O)I
PubChem CID	70862

Physical properties
Physical form	Solid
LogP (XLogP3)	3.9
H-bond donors / acceptors	2 / 4
TPSA	66.8 Å²
Synonyms	2-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)acetic acid, 3,5-Diiodothyroacetic acid, Diac, 4-(4-Hydroxyphenoxy)-3,5-diiodobenzeneacetic acid, Levothyroxine Impurity D (Stage-6 ), 4-(4-Hydroxyphenoxy)-3,5-diiodophenylacetic acid, 3,5-Diiodo Thyroacetic Acid, Benzeneacetic acid, 4-(4-hydroxyphenoxy)-3,5-diiodo-, [4-(4-hydroxyphenoxy)-3,5-diiodophenyl]acetic acid, [4-(p-Hydroxyphenoxy)-3,5-diiodophenyl]acetic Acid, Benzeneacetic acid,4-(4-hydroxyphenoxy)-3,5-diiodo-, US10322118, Entry 3

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302+H312+H332Harmful if swallowed, in contact with skin or if inhaled
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled

Precautionary statements: P261, P264, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P317, P321, P330, P362 + P364, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Levothyroxine Impurity D (Stage-6)?

The CAS Registry Number of Levothyroxine Impurity D (Stage-6) is 1155-40-4. It is also known as 2-(4-(4-hydroxyphenoxy)-3,5-diiodophenyl)acetic acid, 3,5-Diiodothyroacetic acid, Diac.

What is the molecular formula and molecular weight of Levothyroxine Impurity D (Stage-6)?

Levothyroxine Impurity D (Stage-6) has the molecular formula C14H10I2O4 and a molecular weight of 496.03 g/mol. Its IUPAC name is 2-[4-(4-hydroxyphenoxy)-3,5-diiodophenyl]acetic acid.

What is Levothyroxine Impurity D (Stage-6) used for?

Levothyroxine Impurity D (Stage-6) is supplied as a characterised reference material related to Levothyroxine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Levothyroxine Impurity D (Stage-6) can I order?

We supply Levothyroxine Impurity D (Stage-6) in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Levothyroxine Impurity D (Stage-6)?

Yes. Every lot of Levothyroxine Impurity D (Stage-6) is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Levothyroxine Impurity D (Stage-6) be shipped internationally?

Yes. Levothyroxine Impurity D (Stage-6) is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.