Lofepramine

Name: Lofepramine
Brand: Vaqora Chemicals
SKU: VQ-038099

About Lofepramine

Lofepramine (CAS 23047-25-8) is a high-purity reference standard of Lofepramine offered by Vaqora Chemicals. Formula C26H27ClN2O, molecular weight 419.0 g/mol. The IUPAC name is 1-(4-chlorophenyl)-2-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methylamino]ethanone. Common synonyms include Lopramine and Leo 640.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Danger” with 3 hazard statements. Review the Safety Data Sheet before use.

Laboratories use this Lofepramine standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Lofepramine in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Lofepramine

View every impurity, metabolite and intermediate we list for Lofepramine.

Lofepramine impurities

Specifications & identifiers

Chemical identifiers
Product name	Lofepramine
Catalogue No.	VQ-038099
CAS Number	23047-25-8
IUPAC name	1-(4-chlorophenyl)-2-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methylamino]ethanone
Molecular formula	C₂₆H₂₇ClN₂O
Molecular weight	419 g/mol
Exact mass	418.1812
Grade	Reference Standard
HSN code	38229090
InChIKey	SAPNXPWPAUFAJU-UHFFFAOYSA-N
SMILES	CN(CCCN1C2=CC=CC=C2CCC3=CC=CC=C31)CC(=O)C4=CC=C(C=C4)Cl
PubChem CID	3947

Physical properties
Physical form	Solid
LogP (XLogP3)	6.8
H-bond donors / acceptors	0 / 3
TPSA	23.6 Å²
Synonyms	Lopramine, 4'-Chlor-2-((3-(10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl)methylamino)acetophenon, 4'-Chloro-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]acetophenone, Leo 640, Acetophenone, 4'-chloro-2-((3-(10,11-dihydro-5H-dibenz(b,f)azepin5-yl)propyl)methylamino)-, 4'-chloro-2-((3-(10,11-dihydro-5H-dibenz(b,f)azepin5-yl)propyl)methylamino)acetophenone, Gamanil (Salt/Mix), Gamonil (Salt/Mix), Timelit (Salt/Mix), Tymelyt (Salt/Mix), Lofepramine - Bio-X trade mark

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H336May cause drowsiness or dizziness
H370Causes damage to organs
H373May causes damage to organs through prolonged or repeated exposure

Precautionary statements: P260, P261, P264, P270, P271, P304 + P340, P308 + P316, P319, P321, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Lofepramine?

The CAS Registry Number of Lofepramine is 23047-25-8. It is also known as Lopramine, 4'-Chlor-2-((3-(10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl)methylamino)acetophenon, 4'-Chloro-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]acetophenone.

What is the molecular formula and molecular weight of Lofepramine?

Lofepramine has the molecular formula C26H27ClN2O and a molecular weight of 419 g/mol. Its IUPAC name is 1-(4-chlorophenyl)-2-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methylamino]ethanone.

What is Lofepramine used for?

Lofepramine is supplied as a characterised reference material related to Lofepramine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Lofepramine can I order?

We supply Lofepramine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Lofepramine?

Yes. Every lot of Lofepramine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Lofepramine be shipped internationally?

Yes. Lofepramine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.