Lorazepam EP Impurity B

Name: Lorazepam EP Impurity B
Brand: Vaqora Chemicals
SKU: VQ-044889

About Lorazepam EP Impurity B

Lorazepam EP Impurity B (CAS 2848-96-6) is a pharmacopeial impurity of Lorazepam offered by Vaqora Chemicals. Formula C17H12Cl2N2O3, molecular weight 363.2 g/mol. Systematically, it is named [7-chloro-5-(2-chlorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl] acetate. Alternative names: Lorazepam Acetate and Lorazepam - Impurity B.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

As a characterised impurity of Lorazepam, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Lorazepam EP Impurity B is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Lorazepam

View every impurity, metabolite and intermediate we list for Lorazepam.

Lorazepam impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Lorazepam EP Impurity B
Catalogue No.	VQ-044889
CAS Number	2848-96-6
IUPAC name	[7-chloro-5-(2-chlorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl] acetate
Molecular formula	C₁₇H₁₂Cl₂N₂O₃
Molecular weight	363.2 g/mol
Exact mass	362.0225
Grade	Reference Standard
HSN code	38229090
InChIKey	CYDZMDOLVUBPNL-UHFFFAOYSA-N
SMILES	CC(=O)OC1C(=O)NC2=C(C=C(C=C2)Cl)C(=N1)C3=CC=CC=C3Cl
PubChem CID	17836

Physical properties
Physical form	Solid
LogP (XLogP3)	3
H-bond donors / acceptors	1 / 4
TPSA	67.8 Å²
Synonyms	Lorazepam Acetate, Lorazepam - Impurity B, 2H-1,4-Benzodiazepin-2-one, 3-(acetyloxy)-7-chloro-5-(2-chlorophenyl)-1,3-dihydro-, acetic acid [7-chloro-5-(2-chlorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl] ester, 3-(acetyloxy)-7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2h-1,4-benzodiazepin-2-one, Lorazepam Impurity 8, 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-2-oxo-2H-1,4-benzodiazepin-3-yl acetate, 7-Chloro-5-(2-chlorophenyl)-2-hydroxy-3H-1,4-benzodiazepin-3-yl acetate, 7-chloro-5-(2-chlorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl acetate

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Environmental hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H361Suspected of damaging fertility or the unborn child
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects

Precautionary statements: P203, P264, P270, P273, P280, P301 + P317, P318, P330, P391, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Lorazepam EP Impurity B?

The CAS Registry Number of Lorazepam EP Impurity B is 2848-96-6. It is also known as Lorazepam Acetate, Lorazepam - Impurity B, 2H-1,4-Benzodiazepin-2-one, 3-(acetyloxy)-7-chloro-5-(2-chlorophenyl)-1,3-dihydro-.

What is the molecular formula and molecular weight of Lorazepam EP Impurity B?

Lorazepam EP Impurity B has the molecular formula C17H12Cl2N2O3 and a molecular weight of 363.2 g/mol. Its IUPAC name is [7-chloro-5-(2-chlorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepin-3-yl] acetate.

What is Lorazepam EP Impurity B used for?

Lorazepam EP Impurity B is supplied as a characterised reference material related to Lorazepam. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Lorazepam EP Impurity B can I order?

We supply Lorazepam EP Impurity B in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Lorazepam EP Impurity B?

Yes. Every lot of Lorazepam EP Impurity B is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Lorazepam EP Impurity B be shipped internationally?

Yes. Lorazepam EP Impurity B is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.