Metoprolol EP Impurity E

Name: Metoprolol EP Impurity E
Brand: Vaqora Chemicals
SKU: VQ-026659

About Metoprolol EP Impurity E

Metoprolol EP Impurity E is a pharmacopeial impurity of Metoprolol carrying the CAS registry number 163685-38-9. The compound has the formula C15H25NO3, corresponding to a molecular weight of 267.36 g/mol. Systematically, it is named 1-[2-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol. It is also known as Metoprolol Succinate - Impurity E or Metoprolol Tartrate - Impurity E.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Warning” with 6 hazard statements. Review the Safety Data Sheet before use.

Pharmaceutical QC and development laboratories use this impurity standard of Metoprolol to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Metoprolol EP Impurity E is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Metoprolol

View every impurity, metabolite and intermediate we list for Metoprolol.

Metoprolol impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Metoprolol EP Impurity E
Catalogue No.	VQ-026659
CAS Number	163685-38-9
IUPAC name	1-[2-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol
Molecular formula	C₁₅H₂₅NO₃
Molecular weight	267.36 g/mol
Exact mass	267.1834
Grade	Reference Standard
HSN code	38229090
InChIKey	RQZBCLSVVDPFIC-UHFFFAOYSA-N
SMILES	CC(C)NCC(COC1=CC=CC=C1CCOC)O
PubChem CID	14029276

Physical properties
Physical form	Solid
LogP (XLogP3)	2.1
H-bond donors / acceptors	2 / 4
TPSA	50.7 Å²
Synonyms	Metoprolol Succinate - Impurity E, Metoprolol Tartrate - Impurity E, 1-[2-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-Propanol, 1-(2-(2-methoxyethyl)phenoxy)-3-((1-methylethyl)amino)-2-propanol, 1-(Isopropylamino)-3-(2-(2-methoxyethyl)phenoxy)propan-2-ol, ortho-Metoprolol, Metoprolol IMpurity 05, 2-Propanol, 1-(2-(2-methoxyethyl)phenoxy)-3-((1-methylethyl)amino)-, (2RS)-1-(2-(2-Methoxyethyl)phenoxy)-3-((1-methylethyl)amino)propan-2-ol, 1-(2-(2-Methoxyethyl)phenoxy)-3-((1-methylethyl)amino)propan-2-ol, (2RS)-, 1-(Isopropylamino)-3-[2-(2-methoxyethyl)phenoxy]-2-propanol, (2RS)-1-[2-(2-Methoxyethyl)phenoxy]- 3-[(1-methylethyl)amino]propan-2-ol

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Environmental hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H361Suspected of damaging fertility or the unborn child
H411Toxic to aquatic life with long lasting effects

Precautionary statements: P203, P261, P264, P264 + P265, P270, P271, P273, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P318, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P391, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Metoprolol EP Impurity E?

The CAS Registry Number of Metoprolol EP Impurity E is 163685-38-9. It is also known as Metoprolol Succinate - Impurity E, Metoprolol Tartrate - Impurity E, 1-[2-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-Propanol.

What is the molecular formula and molecular weight of Metoprolol EP Impurity E?

Metoprolol EP Impurity E has the molecular formula C15H25NO3 and a molecular weight of 267.36 g/mol. Its IUPAC name is 1-[2-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol.

What is Metoprolol EP Impurity E used for?

Metoprolol EP Impurity E is supplied as a characterised reference material related to Metoprolol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Metoprolol EP Impurity E can I order?

We supply Metoprolol EP Impurity E in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Metoprolol EP Impurity E?

Yes. Every lot of Metoprolol EP Impurity E is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Metoprolol EP Impurity E be shipped internationally?

Yes. Metoprolol EP Impurity E is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.