N-Desacetyl O4-Desmethyl Apremilast

Name: N-Desacetyl O4-Desmethyl Apremilast
Brand: Vaqora Chemicals
SKU: VQ-021611

About N-Desacetyl O4-Desmethyl Apremilast

Listed under CAS 1384440-16-7, N-Desacetyl O4-Desmethyl Apremilast is a metabolite or degradation product of Apremilast available from Vaqora Chemicals. The compound has the formula C19H20N2O6S, corresponding to a molecular weight of 404.4 g/mol. Its systematic (IUPAC) name is 4-amino-2-[(1S)-1-(3-ethoxy-4-hydroxyphenyl)-2-methylsulfonylethyl]isoindole-1,3-dione. Common synonyms include O-Demethyl-N-deacetyl apremilast and Apremilast (m4).

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Good laboratory practice and suitable PPE are recommended during handling.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Apremilast, as well as in QC testing and ANDA/DMF documentation. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Apremilast

View every impurity, metabolite and intermediate we list for Apremilast.

Apremilast impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Desacetyl O4-Desmethyl Apremilast
Catalogue No.	VQ-021611
CAS Number	1384440-16-7
IUPAC name	4-amino-2-[(1S)-1-(3-ethoxy-4-hydroxyphenyl)-2-methylsulfonylethyl]isoindole-1,3-dione
Molecular formula	C₁₉H₂₀N₂O₆S
Molecular weight	404.4 g/mol
Exact mass	404.1042
Grade	Reference Standard
HSN code	38229090
InChIKey	RNEPXCGHBYQJJA-CQSZACIVSA-N
SMILES	CCOC1=C(C=CC(=C1)[C@@H](CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)N)O
PubChem CID	57524404

Physical properties
Physical form	Solid
LogP (XLogP3)	1.7
H-bond donors / acceptors	2 / 7
TPSA	135 Å²
Synonyms	(S)-4-Amino-2-(1-(3-ethoxy-4-hydroxyphenyl)-2-(methylsulfonyl)ethyl)isoindoline-1,3-dione, O-Demethyl-N-deacetyl apremilast, Apremilast (m4), o-Desmethyl-N-deacetyl apremilast, Apremilast metabolite M4, (S)-4-amino-2-[1-(3-ethoxy-4-hydroxy-phenyl)-2-methanesulfonyl-ethyl]-isoindole-1,3-dione

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Desacetyl O4-Desmethyl Apremilast?

The CAS Registry Number of N-Desacetyl O4-Desmethyl Apremilast is 1384440-16-7. It is also known as (S)-4-Amino-2-(1-(3-ethoxy-4-hydroxyphenyl)-2-(methylsulfonyl)ethyl)isoindoline-1,3-dione, O-Demethyl-N-deacetyl apremilast, Apremilast (m4).

What is the molecular formula and molecular weight of N-Desacetyl O4-Desmethyl Apremilast?

N-Desacetyl O4-Desmethyl Apremilast has the molecular formula C19H20N2O6S and a molecular weight of 404.4 g/mol. Its IUPAC name is 4-amino-2-[(1S)-1-(3-ethoxy-4-hydroxyphenyl)-2-methylsulfonylethyl]isoindole-1,3-dione.

What is N-Desacetyl O4-Desmethyl Apremilast used for?

N-Desacetyl O4-Desmethyl Apremilast is supplied as a characterised reference material related to Apremilast. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Desacetyl O4-Desmethyl Apremilast can I order?

We supply N-Desacetyl O4-Desmethyl Apremilast in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Desacetyl O4-Desmethyl Apremilast?

Yes. Every lot of N-Desacetyl O4-Desmethyl Apremilast is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Desacetyl O4-Desmethyl Apremilast be shipped internationally?

Yes. We export N-Desacetyl O4-Desmethyl Apremilast worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.