N-Desmethyl Sorafenib (Pyridine)-N-oxide

Name: N-Desmethyl Sorafenib (Pyridine)-N-oxide
Brand: Vaqora Chemicals
SKU: VQ-043895

About N-Desmethyl Sorafenib (Pyridine)-N-oxide

Vaqora Chemicals supplies N-Desmethyl Sorafenib (Pyridine)-N-oxide, a metabolite or degradation product of Sorafenib registered under CAS number 583840-04-4. Formula C20H14ClF3N4O4, molecular weight 466.8 g/mol. Its systematic (IUPAC) name is 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1-oxidopyridin-1-ium-2-carboxamide. Alternative names: Sorafenib N-Desmethyl N-Oxide and Des-srf-nox.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Good laboratory practice and suitable PPE are recommended during handling.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Sorafenib, as well as in QC testing and ANDA/DMF documentation. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

We offer N-Desmethyl Sorafenib (Pyridine)-N-oxide in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Sorafenib

View every impurity, metabolite and intermediate we list for Sorafenib.

Sorafenib impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Desmethyl Sorafenib (Pyridine)-N-oxide
Catalogue No.	VQ-043895
CAS Number	583840-04-4
IUPAC name	4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1-oxidopyridin-1-ium-2-carboxamide
Molecular formula	C₂₀H₁₄ClF₃N₄O₄
Molecular weight	466.8 g/mol
Exact mass	466.0656
Grade	Reference Standard
HSN code	38229090
InChIKey	VYTLLTTWWZIYME-UHFFFAOYSA-N
SMILES	C1=CC(=CC=C1NC(=O)NC2=CC(=C(C=C2)Cl)C(F)(F)F)OC3=CC(=[N+](C=C3)[O-])C(=O)N
PubChem CID	10288613

Physical properties
Physical form	Solid
LogP (XLogP3)	3.2
H-bond donors / acceptors	3 / 7
TPSA	119 Å²
Synonyms	Sorafenib N-Desmethyl N-Oxide, 2-Carbamoyl-4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)pyridine 1-oxide, Des-srf-nox, Des-srf-N-oxide, Sorafenib metabolite M5, N-Desmethylsorafenib N-oxide, 4,6-bis(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Desmethyl Sorafenib (Pyridine)-N-oxide?

The CAS Registry Number of N-Desmethyl Sorafenib (Pyridine)-N-oxide is 583840-04-4. It is also known as Sorafenib N-Desmethyl N-Oxide, 2-Carbamoyl-4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)pyridine 1-oxide, Des-srf-nox.

What is the molecular formula and molecular weight of N-Desmethyl Sorafenib (Pyridine)-N-oxide?

N-Desmethyl Sorafenib (Pyridine)-N-oxide has the molecular formula C20H14ClF3N4O4 and a molecular weight of 466.8 g/mol. Its IUPAC name is 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1-oxidopyridin-1-ium-2-carboxamide.

What is N-Desmethyl Sorafenib (Pyridine)-N-oxide used for?

N-Desmethyl Sorafenib (Pyridine)-N-oxide is supplied as a characterised reference material related to Sorafenib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Desmethyl Sorafenib (Pyridine)-N-oxide can I order?

We supply N-Desmethyl Sorafenib (Pyridine)-N-oxide in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Desmethyl Sorafenib (Pyridine)-N-oxide?

Yes. Every lot of N-Desmethyl Sorafenib (Pyridine)-N-oxide is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Desmethyl Sorafenib (Pyridine)-N-oxide be shipped internationally?

Yes. We export N-Desmethyl Sorafenib (Pyridine)-N-oxide worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.