N-Nitroso-D-proline

Name: N-Nitroso-D-proline
Brand: Vaqora Chemicals
SKU: VQ-042901

About N-Nitroso-D-proline

N-Nitroso-D-proline (CAS 42022-03-7) is a nitrosamine impurity of Proline offered by Vaqora Chemicals. The compound has the formula C5H8N2O3, corresponding to a molecular weight of 144.13 g/mol. Its systematic (IUPAC) name is (2R)-1-nitrosopyrrolidine-2-carboxylic acid. Common synonyms include N-Nitroso-D-proline (Mixture of Isomers) and (R)-1-Nitrosopyrrolidine-2-carboxylic acid.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Warning” with 6 hazard statements. Review the Safety Data Sheet before use.

It is used as a reference standard for trace-level detection and quantitation of nitrosamine impurities by LC-MS/MS or GC-MS, supporting nitrosamine risk assessments for Proline, method validation (AMV) and regulatory filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

We offer N-Nitroso-D-proline in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Proline

View every impurity, metabolite and intermediate we list for Proline.

Proline impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Nitroso-D-proline
Catalogue No.	VQ-042901
CAS Number	42022-03-7
IUPAC name	(2R)-1-nitrosopyrrolidine-2-carboxylic acid
Molecular formula	C₅H₈N₂O₃
Molecular weight	144.13 g/mol
Exact mass	144.0535
Grade	Reference Standard
HSN code	38229090
InChIKey	WLKPHJWEIIAIFW-SCSAIBSYSA-N
SMILES	C1C[C@@H](N(C1)N=O)C(=O)O
PubChem CID	29985925

Physical properties
Physical form	Solid
LogP (XLogP3)	0.3
H-bond donors / acceptors	1 / 5
TPSA	70 Å²

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H341Suspected of causing genetic defects
H351Suspected of causing cancer

Precautionary statements: P203, P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P318, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Nitroso-D-proline?

The CAS Registry Number of N-Nitroso-D-proline is 42022-03-7. It is also known as N-Nitroso-D-proline (Mixture of Isomers), (R)-1-Nitrosopyrrolidine-2-carboxylic acid.

What is the molecular formula and molecular weight of N-Nitroso-D-proline?

N-Nitroso-D-proline has the molecular formula C5H8N2O3 and a molecular weight of 144.13 g/mol. Its IUPAC name is (2R)-1-nitrosopyrrolidine-2-carboxylic acid.

What is N-Nitroso-D-proline used for?

N-Nitroso-D-proline is supplied as a characterised reference material related to Proline. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Nitroso-D-proline can I order?

We supply N-Nitroso-D-proline in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Nitroso-D-proline?

Yes. Every lot of N-Nitroso-D-proline is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Nitroso-D-proline be shipped internationally?

Yes. N-Nitroso-D-proline is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.