N-Nitroso N-Desmethyl Neratinib

Name: N-Nitroso N-Desmethyl Neratinib
Brand: Vaqora Chemicals
SKU: VQ-006929

About N-Nitroso N-Desmethyl Neratinib

N-Nitroso N-Desmethyl Neratinib (CAS 3050754-68-9) is a nitrosamine impurity of Neratinib offered by Vaqora Chemicals, specified at 98% purity. The compound has the formula C29H26ClN7O4, corresponding to a molecular weight of 572.0 g/mol. It is also known as N-nitroso-desmethyl-neratinib.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Handle it with standard laboratory precautions and appropriate personal protective equipment.

Laboratories use this nitrosamine standard to develop and validate highly sensitive LC-MS/MS methods, to confirm limits of detection and to document nitrosamine risk assessments in regulatory submissions. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

We offer N-Nitroso N-Desmethyl Neratinib in 10 mg and 25 mg packs with a batch-specific COA, and ship to customers worldwide. This item is currently in stock for prompt dispatch.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Neratinib

View every impurity, metabolite and intermediate we list for Neratinib.

Neratinib impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Nitroso N-Desmethyl Neratinib
Catalogue No.	VQ-006929
CAS Number	3050754-68-9
IUPAC name	(E)-N-[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-3-cyano-7-ethoxyquinolin-6-yl]-4-[methyl(nitroso)amino]but-2-enamide
Molecular formula	C₂₉H₂₆ClN₇O₄
Molecular weight	572 g/mol
Exact mass	571.1735
Grade	Reference Standard
Purity / assay	98%
HSN code	38229090
InChIKey	CFKCEZQMDLWFGH-SOFGYWHQSA-N
SMILES	CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)/C=C/CN(C)N=O
PubChem CID	172866454

Physical properties
Physical form	Solid
LogP (XLogP3)	4.8
H-bond donors / acceptors	2 / 10
TPSA	142 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Nitroso N-Desmethyl Neratinib?

The CAS Registry Number of N-Nitroso N-Desmethyl Neratinib is 3050754-68-9. It is also known as N-nitroso-desmethyl-neratinib.

What is the molecular formula and molecular weight of N-Nitroso N-Desmethyl Neratinib?

N-Nitroso N-Desmethyl Neratinib has the molecular formula C29H26ClN7O4 and a molecular weight of 572 g/mol. Its IUPAC name is (E)-N-[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-3-cyano-7-ethoxyquinolin-6-yl]-4-[methyl(nitroso)amino]but-2-enamide.

What is N-Nitroso N-Desmethyl Neratinib used for?

N-Nitroso N-Desmethyl Neratinib is supplied as a characterised reference material related to Neratinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Nitroso N-Desmethyl Neratinib can I order?

We supply N-Nitroso N-Desmethyl Neratinib in Reference Standard (98%) grade, in 10 mg, 25 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Nitroso N-Desmethyl Neratinib?

Yes. Every lot of N-Nitroso N-Desmethyl Neratinib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Nitroso N-Desmethyl Neratinib be shipped internationally?

Yes. We export N-Nitroso N-Desmethyl Neratinib worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.