N-Nitrosocimetidine

Name: N-Nitrosocimetidine
Brand: Vaqora Chemicals
SKU: VQ-024971

About N-Nitrosocimetidine

N-Nitrosocimetidine is a nitrosamine impurity of Cimetidine carrying the CAS registry number 73785-40-7. Its molecular formula is C10H15N7OS and its molecular weight is 281.34 g/mol. Systematically, it is named 3-cyano-1-methyl-2-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]-1-nitrosoguanidine. Common synonyms include Nitrosocimetidine and Nitrocimetidine.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

It is used as a reference standard for trace-level detection and quantitation of nitrosamine impurities by LC-MS/MS or GC-MS, supporting nitrosamine risk assessments for Cimetidine, method validation (AMV) and regulatory filings. It is used across pharmaceutical manufacturing and academic and industrial research.

We offer N-Nitrosocimetidine in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Cimetidine

View every impurity, metabolite and intermediate we list for Cimetidine.

Cimetidine impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Nitrosocimetidine
Catalogue No.	VQ-024971
CAS Number	73785-40-7
IUPAC name	3-cyano-1-methyl-2-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]-1-nitrosoguanidine
Molecular formula	C₁₀H₁₅N₇OS
Molecular weight	281.34 g/mol
Exact mass	281.1059
Grade	Reference Standard
HSN code	38229090
InChIKey	LFTUYYPQNCJQGN-UHFFFAOYSA-N
SMILES	CC1=C(N=CN1)CSCCN=C(NC#N)N(C)N=O
PubChem CID	52445

Physical properties
Physical form	Solid
LogP (XLogP3)	0.7
H-bond donors / acceptors	2 / 6
TPSA	135 Å²
Synonyms	Nitrosocimetidine, Nitrocimetidine, Nitrosocimetidine, N-, N-Nitroso Cimetidine 1, 2-cyano-1-methyl-3-(2-{[(4-methyl-1H-imidazol-5-yl)methyl]thio}ethyl)-1-nitrosoguanidine, Guanidine, 2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)-1-nitroso-

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
H341Suspected of causing genetic defects
H351Suspected of causing cancer

Precautionary statements: P203, P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P317, P318, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Nitrosocimetidine?

The CAS Registry Number of N-Nitrosocimetidine is 73785-40-7. It is also known as Nitrosocimetidine, Nitrocimetidine, Nitrosocimetidine, N-.

What is the molecular formula and molecular weight of N-Nitrosocimetidine?

N-Nitrosocimetidine has the molecular formula C10H15N7OS and a molecular weight of 281.34 g/mol. Its IUPAC name is 3-cyano-1-methyl-2-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]-1-nitrosoguanidine.

What is N-Nitrosocimetidine used for?

N-Nitrosocimetidine is supplied as a characterised reference material related to Cimetidine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Nitrosocimetidine can I order?

We supply N-Nitrosocimetidine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Nitrosocimetidine?

Yes. Every lot of N-Nitrosocimetidine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Nitrosocimetidine be shipped internationally?

Yes. N-Nitrosocimetidine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.