Cimetidine EP Impurity A

Name: Cimetidine EP Impurity A
Brand: Vaqora Chemicals
SKU: VQ-022183

About Cimetidine EP Impurity A

Cimetidine EP Impurity A (CAS 52378-40-2) is a pharmacopeial impurity of Cimetidine offered by Vaqora Chemicals. With the molecular formula C10H15N5S2, it has a molar mass of 269.4 g/mol. Systematically, it is named methyl N-cyano-N'-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]carbamimidothioate. It is also known as Cimetidine Hydrochloride - Impurity A.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

As a characterised impurity of Cimetidine, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Cimetidine EP Impurity A is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Cimetidine

View every impurity, metabolite and intermediate we list for Cimetidine.

Cimetidine impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Cimetidine EP Impurity A
Catalogue No.	VQ-022183
CAS Number	52378-40-2
IUPAC name	methyl N-cyano-N'-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]carbamimidothioate
Molecular formula	C₁₀H₁₅N₅S₂
Molecular weight	269.4 g/mol
Exact mass	269.0769
Grade	Reference Standard
HSN code	38229090
InChIKey	WSUNDBVVUCLXTG-UHFFFAOYSA-N
SMILES	CC1=C(N=CN1)CSCCN=C(NC#N)SC
PubChem CID	103630

Physical properties
Physical form	Solid
LogP (XLogP3)	1.4
H-bond donors / acceptors	2 / 5
TPSA	127 Å²
Synonyms	Cimetidine Hydrochloride - Impurity A, 1-Cyano-2-methyl-3-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)isothiourea, 1-cyano-2-methyl-3-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]isothiourea, N-Cyano-N'-[2-[(4-methyl-5-imidazolyl)methylthio]ethyl]-S-methylisothiourea, N-Cyano-N'-2-[(5-methyl-1H-imidazol-4-yl)methylthio]ethyl-S-methylisothiourea, (E)-methyl N'-cyano-N-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)carbamimidothioate, methyl N'-cyano-N-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)carbamimidothioate, Methyl N-cyano-N'-[2-[[(4-methyl-1H-imidazol-5-yl)methyl]thio]ethyl]carbamimidothioate, 3-Cyano-2-methyl-1-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]sulphanyl]ethyl]isothiourea, N-cyano-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-S-methyl isothiourea, N-cyano-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-S-methylisothiourea, N-cyano-N'-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]-S-methylisothiourea

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H302+H312+H332Harmful if swallowed, in contact with skin or if inhaled
H302Harmful if swallowed
H312Harmful in contact with skin
H317May cause an allergic skin reaction
H332Harmful if inhaled
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H361Suspected of damaging fertility or the unborn child

Precautionary statements: P203, P233, P260, P261, P264, P270, P271, P272, P280, P284, P301 + P317, P302 + P352, P304 + P340, P317, P318, P321, P330, P333 + P317, P342 + P316, P362 + P364, P403, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Cimetidine EP Impurity A?

The CAS Registry Number of Cimetidine EP Impurity A is 52378-40-2. It is also known as Cimetidine Hydrochloride - Impurity A, 1-Cyano-2-methyl-3-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)isothiourea, 1-cyano-2-methyl-3-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]isothiourea.

What is the molecular formula and molecular weight of Cimetidine EP Impurity A?

Cimetidine EP Impurity A has the molecular formula C10H15N5S2 and a molecular weight of 269.4 g/mol. Its IUPAC name is methyl N-cyano-N'-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]carbamimidothioate.

What is Cimetidine EP Impurity A used for?

Cimetidine EP Impurity A is supplied as a characterised reference material related to Cimetidine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Cimetidine EP Impurity A can I order?

We supply Cimetidine EP Impurity A in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Cimetidine EP Impurity A?

Yes. Every lot of Cimetidine EP Impurity A is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Cimetidine EP Impurity A be shipped internationally?

Yes. Cimetidine EP Impurity A is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.