Nicotinamide-d4

Name: Nicotinamide-d4
Brand: Vaqora Chemicals
SKU: VQ-038610

About Nicotinamide-d4

Nicotinamide-d4 is a stable isotope labelled analogue related to Nicotinamide carrying the CAS registry number 347841-88-7. With the molecular formula C6H6N2O, it has a molar mass of 126.15 g/mol. Its systematic (IUPAC) name is 2,4,5,6-tetradeuteriopyridine-3-carboxamide. It is also known as Nicotinamide-2,4,5,6-D4 or (~2~H_4_)Pyridine-3-carboxamide.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

This isotope-labelled compound is used as an internal standard for LC-MS and LC-MS/MS quantitation of Nicotinamide and related analytes in bioanalytical, pharmacokinetic and impurity studies. It is used across pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Nicotinamide-d4 in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

LC-MS/MS internal standard
Bioanalytical quantitation
Pharmacokinetic studies

Industries

Related to Nicotinamide

View every impurity, metabolite and intermediate we list for Nicotinamide.

Nicotinamide impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Nicotinamide-d4
Catalogue No.	VQ-038610
CAS Number	347841-88-7
IUPAC name	2,4,5,6-tetradeuteriopyridine-3-carboxamide
Molecular formula	C₆H₆N₂O
Molecular weight	126.15 g/mol
Exact mass	126.0731
Grade	Reference Standard
HSN code	38229090
InChIKey	DFPAKSUCGFBDDF-RHQRLBAQSA-N
SMILES	[2H]C1=C(C(=C(N=C1[2H])[2H])C(=O)N)[2H]
PubChem CID	15554909

Physical properties
Physical form	Solid
LogP (XLogP3)	-0.4
H-bond donors / acceptors	1 / 2
TPSA	56 Å²

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Nicotinamide-d4?

The CAS Registry Number of Nicotinamide-d4 is 347841-88-7. It is also known as Nicotinamide-2,4,5,6-D4, (~2~H_4_)Pyridine-3-carboxamide, Nicotinamide-d4 (Major).

What is the molecular formula and molecular weight of Nicotinamide-d4?

Nicotinamide-d4 has the molecular formula C6H6N2O and a molecular weight of 126.15 g/mol. Its IUPAC name is 2,4,5,6-tetradeuteriopyridine-3-carboxamide.

What is Nicotinamide-d4 used for?

Nicotinamide-d4 is supplied as a characterised reference material related to Nicotinamide. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Nicotinamide-d4 can I order?

We supply Nicotinamide-d4 in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Nicotinamide-d4?

Yes. Every lot of Nicotinamide-d4 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Nicotinamide-d4 be shipped internationally?

Yes. Nicotinamide-d4 is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.