Nicotinic Acid-d4

Name: Nicotinic Acid-d4
Brand: Vaqora Chemicals
SKU: VQ-038629

About Nicotinic Acid-d4

Nicotinic Acid-d4 (CAS 66148-15-0) is a stable isotope labelled analogue related to Nicotinic Acid offered by Vaqora Chemicals. Formula C6H5NO2, molecular weight 127.13 g/mol. The IUPAC name is 2,4,5,6-tetradeuteriopyridine-3-carboxylic acid. Common synonyms include Niacin-d4 (Nicotinic Acid-d4) and Nicotinic-d4 Acid.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

Its mass shift relative to the unlabelled analyte makes it a dependable internal standard for LC-MS/MS assays, improving accuracy in bioanalysis, therapeutic drug monitoring and method validation. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

LC-MS/MS internal standard
Bioanalytical quantitation
Pharmacokinetic studies

Industries

Related to Nicotinic Acid

View every impurity, metabolite and intermediate we list for Nicotinic Acid.

Nicotinic Acid impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Nicotinic Acid-d4
Catalogue No.	VQ-038629
CAS Number	66148-15-0
IUPAC name	2,4,5,6-tetradeuteriopyridine-3-carboxylic acid
Molecular formula	C₆H₅NO₂
Molecular weight	127.13 g/mol
Exact mass	127.0571
Grade	Reference Standard
HSN code	38229090
InChIKey	PVNIIMVLHYAWGP-RHQRLBAQSA-N
SMILES	[2H]C1=C(C(=C(N=C1[2H])[2H])C(=O)O)[2H]
PubChem CID	12198448

Physical properties
Physical form	Solid
LogP (XLogP3)	0.4
H-bond donors / acceptors	1 / 3
TPSA	50.2 Å²
Synonyms	Niacin-d4 (Nicotinic Acid-d4), Nicotinic-d4 Acid, Niacin-d4, Vitamin B3-d4, 3-Pyridine-d4-carboxylic acid, d4-nicotinic acid, (~2~H_4_)Pyridine-3-carboxylic acid, 3-Pyridine-2,4,5,6-d4-carboxylic acid, Vitamin B 3-d4, Pyridine-3-carboxylic Acid-d4, 3-Picolinic Acid-d4, Niacin-d4

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Nicotinic Acid-d4?

The CAS Registry Number of Nicotinic Acid-d4 is 66148-15-0. It is also known as Niacin-d4 (Nicotinic Acid-d4), Nicotinic-d4 Acid, Niacin-d4.

What is the molecular formula and molecular weight of Nicotinic Acid-d4?

Nicotinic Acid-d4 has the molecular formula C6H5NO2 and a molecular weight of 127.13 g/mol. Its IUPAC name is 2,4,5,6-tetradeuteriopyridine-3-carboxylic acid.

What is Nicotinic Acid-d4 used for?

Nicotinic Acid-d4 is supplied as a characterised reference material related to Nicotinic Acid. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Nicotinic Acid-d4 can I order?

We supply Nicotinic Acid-d4 in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Nicotinic Acid-d4?

Yes. Every lot of Nicotinic Acid-d4 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Nicotinic Acid-d4 be shipped internationally?

Yes. Nicotinic Acid-d4 is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.