O-Desmorpholinopropyl Gefitinib

Name: O-Desmorpholinopropyl Gefitinib
Brand: Vaqora Chemicals
SKU: VQ-025968

About O-Desmorpholinopropyl Gefitinib

O-Desmorpholinopropyl Gefitinib is a metabolite or degradation product of Gefitinib carrying the CAS registry number 184475-71-6. Its molecular formula is C15H11ClFN3O2 and its molecular weight is 319.72 g/mol. The IUPAC name is 4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-ol. Common synonyms include Des-Gefitinib and CS-M2999.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Gefitinib, as well as in QC testing and ANDA/DMF documentation. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

We offer O-Desmorpholinopropyl Gefitinib in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling
Fine chemical synthesis

Industries

Related to Gefitinib

View every impurity, metabolite and intermediate we list for Gefitinib.

Gefitinib impurities

Specifications & identifiers

Chemical identifiers
Product name	O-Desmorpholinopropyl Gefitinib
Catalogue No.	VQ-025968
CAS Number	184475-71-6
IUPAC name	4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-ol
Molecular formula	C₁₅H₁₁ClFN₃O₂
Molecular weight	319.72 g/mol
Exact mass	319.0524
Grade	Reference Standard
HSN code	38229090
InChIKey	JLVTVCRXFMLUIF-UHFFFAOYSA-N
SMILES	COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)O
PubChem CID	10471217

Physical properties
Physical form	Solid
LogP (XLogP3)	3.8
H-bond donors / acceptors	2 / 6
TPSA	67.3 Å²
Synonyms	4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-ol, 4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-ol, 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol, Des-Gefitinib, 4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinol, 4-(3-chloro-4-fluoro-anilino)-7-methoxy-quinazolin-6-ol, 4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolino, 4-(3-Chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline, 4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-7-methoxy-quinazolin-6-ol, 4-[(3-chloro-4-fluoro-phenyl)amino]-6-hydroxy-7-methoxy-quinazoline, 6-Quinazolinol, 4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-, CS-M2999

Safety & hazard information (GHS)

Corrosive

Harmful / irritant

Signal word: Danger

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
H412Harmful to aquatic life with long lasting effects

Precautionary statements: P261, P264, P264 + P265, P270, P271, P273, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P354 + P338, P317, P319, P321, P330, P332 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of O-Desmorpholinopropyl Gefitinib?

The CAS Registry Number of O-Desmorpholinopropyl Gefitinib is 184475-71-6. It is also known as 4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-ol, 4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-ol, 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol.

What is the molecular formula and molecular weight of O-Desmorpholinopropyl Gefitinib?

O-Desmorpholinopropyl Gefitinib has the molecular formula C15H11ClFN3O2 and a molecular weight of 319.72 g/mol. Its IUPAC name is 4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-ol.

What is O-Desmorpholinopropyl Gefitinib used for?

O-Desmorpholinopropyl Gefitinib is supplied as a characterised reference material related to Gefitinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of O-Desmorpholinopropyl Gefitinib can I order?

We supply O-Desmorpholinopropyl Gefitinib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with O-Desmorpholinopropyl Gefitinib?

Yes. Every lot of O-Desmorpholinopropyl Gefitinib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can O-Desmorpholinopropyl Gefitinib be shipped internationally?

Yes. O-Desmorpholinopropyl Gefitinib is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.