Pralatrexate

Name: Pralatrexate
Brand: Vaqora Chemicals
SKU: VQ-027561

About Pralatrexate

Pralatrexate (CAS 146464-95-1) is a high-purity reference standard of Pralatrexate offered by Vaqora Chemicals. Its molecular formula is C23H23N7O5 and its molecular weight is 477.5 g/mol. The IUPAC name is (2S)-2-[[4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl]amino]pentanedioic acid. It is also known as 10-Propargyl-10-deazaaminopterin.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

As a reference sample of Pralatrexate, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Pralatrexate is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Pralatrexate

View every impurity, metabolite and intermediate we list for Pralatrexate.

Pralatrexate impurities

Specifications & identifiers

Chemical identifiers
Product name	Pralatrexate
Catalogue No.	VQ-027561
CAS Number	146464-95-1
IUPAC name	(2S)-2-[[4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl]amino]pentanedioic acid
Molecular formula	C₂₃H₂₃N₇O₅
Molecular weight	477.5 g/mol
Exact mass	477.1761
Grade	Reference Standard
HSN code	38229090
InChIKey	OGSBUKJUDHAQEA-WMCAAGNKSA-N
SMILES	C#CCC(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
PubChem CID	148121

Physical properties
Physical form	Solid
LogP (XLogP3)	-0.9
H-bond donors / acceptors	5 / 11
TPSA	207 Å²
Synonyms	10-Propargyl-10-deazaaminopterin, N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid, N-{4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl}-L-glutamic acid, (2S)-2-({4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl}amino)pentanedioic acid, L-Glutamic acid, N-(4-(1-((2,4-diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-, (2S)-2-((4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoyl)amino)pentanedioic acid, N-(4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoyl)-L-glutamic acid, N-(4-(1-((2,4-Diaminopteridin-6-yl)methyl)but-3-yn-1-yl)benzoyl)-L-glutamic Acid, (2S)-2-(4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzamido)pentanedioic acid, L-Glutamic acid, N-[4-[1-[(2,4-diamino-6-pteridinyl)methyl]-3-butyn-1-yl]benzoyl]-, (2S)-2-({4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]phenyl}formamido)pentanedioic acid, (2S)-2-[[4-[1-[(2,4-diaminopteridin-6-yl)methyl]but-3-ynyl]benzoyl]amino]pentanedioic acid

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H311Toxic in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
H340May cause genetic defects
H351Suspected of causing cancer
H360May damage fertility or the unborn child
H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements: P203, P260, P261, P262, P264, P264 + P265, P270, P271, P280, P301 + P316, P302 + P352, P304 + P340, P305 + P351 + P338, P316, P318, P319, P321, P330, P332 + P317, P337 + P317, P361 + P364, P362 + P364, P403 + P233, P405

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Pralatrexate?

The CAS Registry Number of Pralatrexate is 146464-95-1. It is also known as 10-Propargyl-10-deazaaminopterin, N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid, N-{4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl}-L-glutamic acid.

What is the molecular formula and molecular weight of Pralatrexate?

Pralatrexate has the molecular formula C23H23N7O5 and a molecular weight of 477.5 g/mol. Its IUPAC name is (2S)-2-[[4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl]amino]pentanedioic acid.

What is Pralatrexate used for?

Pralatrexate is supplied as a characterised reference material related to Pralatrexate. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Pralatrexate can I order?

We supply Pralatrexate in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Pralatrexate?

Yes. Every lot of Pralatrexate is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Pralatrexate be shipped internationally?

Yes. Pralatrexate is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.