(R)-1-Boc-3-Hydroxypiperidine

Name: (R)-1-Boc-3-Hydroxypiperidine
Brand: Vaqora Chemicals
SKU: VQ-031119

About (R)-1-Boc-3-Hydroxypiperidine

(R)-1-Boc-3-Hydroxypiperidine is a metabolite or degradation product of Ibrutinib carrying the CAS registry number 143900-43-0. With the molecular formula C10H19NO3, it has a molar mass of 201.26 g/mol. Systematically, it is named tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate. Common synonyms include (R)-1-N-Boc-3-hydroxypiperidine and (R)-3-hydroxy-1-boc piperidine.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

Analytical teams use this compound to identify metabolites and degradants of Ibrutinib, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, (R)-1-Boc-3-Hydroxypiperidine is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling
Fine chemical synthesis

Industries

Related to Ibrutinib

View every impurity, metabolite and intermediate we list for Ibrutinib.

Ibrutinib impurities

Specifications & identifiers

Chemical identifiers
Product name	(R)-1-Boc-3-Hydroxypiperidine
Catalogue No.	VQ-031119
CAS Number	143900-43-0
IUPAC name	tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate
Molecular formula	C₁₀H₁₉NO₃
Molecular weight	201.26 g/mol
Exact mass	201.1365
Grade	Reference Standard
HSN code	38229090
InChIKey	UIJXHKXIOCDSEB-MRVPVSSYSA-N
SMILES	CC(C)(C)OC(=O)N1CCC[C@H](C1)O
PubChem CID	1514398

Physical properties
Physical form	Solid
LogP (XLogP3)	1
H-bond donors / acceptors	1 / 3
TPSA	49.8 Å²
Synonyms	(R)-tert-Butyl 3-hydroxypiperidine-1-carboxylate, (R)-1-N-Boc-3-hydroxypiperidine, 1-Piperidinecarboxylic acid, 3-hydroxy-, 1,1-dimethylethyl ester, (3R)-, (R)-3-hydroxy-1-boc piperidine, (3R)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine, tert-butyl (R)-3-hydroxypiperidine-1-carboxylate, (r)-3-hydroxy-piperidine-1-carboxylic acid tert-butyl ester, (R)-1-(tert-butoxycarbonyl)-3-hydroxypiperidine, (r)-tert butyl-3-hydroxypiperidine-1-carboxylate, (R)-tert-butyl 3-hydroxy-1-piperidinecarboxylate, tert-butyl (3R)-3-hydroxypiperidin-1-carboxylate, (R)-1-Boc-3-piperidinol

Safety & hazard information (GHS)

Corrosive

Toxic

Harmful / irritant

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P316, P302 + P352, P304 + P340, P305 + P354 + P338, P317, P319, P321, P330, P332 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of (R)-1-Boc-3-Hydroxypiperidine?

The CAS Registry Number of (R)-1-Boc-3-Hydroxypiperidine is 143900-43-0. It is also known as (R)-tert-Butyl 3-hydroxypiperidine-1-carboxylate, (R)-1-N-Boc-3-hydroxypiperidine, 1-Piperidinecarboxylic acid, 3-hydroxy-, 1,1-dimethylethyl ester, (3R)-.

What is the molecular formula and molecular weight of (R)-1-Boc-3-Hydroxypiperidine?

(R)-1-Boc-3-Hydroxypiperidine has the molecular formula C10H19NO3 and a molecular weight of 201.26 g/mol. Its IUPAC name is tert-butyl (3R)-3-hydroxypiperidine-1-carboxylate.

What is (R)-1-Boc-3-Hydroxypiperidine used for?

(R)-1-Boc-3-Hydroxypiperidine is supplied as a characterised reference material related to Ibrutinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of (R)-1-Boc-3-Hydroxypiperidine can I order?

We supply (R)-1-Boc-3-Hydroxypiperidine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with (R)-1-Boc-3-Hydroxypiperidine?

Yes. Every lot of (R)-1-Boc-3-Hydroxypiperidine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can (R)-1-Boc-3-Hydroxypiperidine be shipped internationally?

Yes. (R)-1-Boc-3-Hydroxypiperidine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.