Rac-Nebivolol

Name: Rac-Nebivolol
Brand: Vaqora Chemicals
SKU: VQ-026838

About Rac-Nebivolol

Rac-Nebivolol (CAS 99200-09-6) is an impurity of Nebivolol offered by Vaqora Chemicals. With the molecular formula C22H25F2NO4, it has a molar mass of 405.4 g/mol. It is also known as Nebivolol or Narbivolol.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. It carries the GHS signal word “Warning” with 6 hazard statements. Review the Safety Data Sheet before use.

Pharmaceutical QC and development laboratories use this impurity standard of Nebivolol to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

We offer Rac-Nebivolol in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Nebivolol

View every impurity, metabolite and intermediate we list for Nebivolol.

Nebivolol impurities

Specifications & identifiers

Chemical identifiers
Product name	Rac-Nebivolol
Catalogue No.	VQ-026838
CAS Number	99200-09-6
IUPAC name	1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl]amino]ethanol
Molecular formula	C₂₂H₂₅F₂NO₄
Molecular weight	405.4 g/mol
Exact mass	405.1752
Grade	Reference Standard
HSN code	38229090
InChIKey	KOHIRBRYDXPAMZ-UHFFFAOYSA-N
SMILES	C1CC2=C(C=CC(=C2)F)OC1C(CNCC(C3CCC4=C(O3)C=CC(=C4)F)O)O
PubChem CID	71301

Physical properties
Physical form	Solid
LogP (XLogP3)	3
H-bond donors / acceptors	3 / 7
TPSA	71 Å²
Synonyms	Nebivolol, Narbivolol, dl-Nebivolol, nebibolol, Hydrochloride, Nebivolol, alpha,alpha'-(iminobis(methylene))bis(6-fluoro-3,4-dihydro)-2H-1-benzopyran-2-methanol, 2,2'-Azanediylbis(1-(6-fluorochroman-2-yl)ethanol), 1-(6-fluorochroman-2-yl)-2-[[2-(6-fluorochroman-2-yl)-2-hydroxy-ethyl]amino]ethanol, alpha,alpha'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol], 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol]

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
H361Suspected of damaging fertility or the unborn child

Precautionary statements: P203, P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P317, P318, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Rac-Nebivolol?

The CAS Registry Number of Rac-Nebivolol is 99200-09-6. It is also known as Nebivolol, Narbivolol, dl-Nebivolol.

What is the molecular formula and molecular weight of Rac-Nebivolol?

Rac-Nebivolol has the molecular formula C22H25F2NO4 and a molecular weight of 405.4 g/mol. Its IUPAC name is 1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl]amino]ethanol.

What is Rac-Nebivolol used for?

Rac-Nebivolol is supplied as a characterised reference material related to Nebivolol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Rac-Nebivolol can I order?

We supply Rac-Nebivolol in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Rac-Nebivolol?

Yes. Every lot of Rac-Nebivolol is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Rac-Nebivolol be shipped internationally?

Yes. Rac-Nebivolol is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.