rac-Nicotine-d4

Name: rac-Nicotine-d4
Brand: Vaqora Chemicals
SKU: VQ-038617

About rac-Nicotine-d4

rac-Nicotine-d4 (CAS 350818-69-8) is a stable isotope labelled analogue related to Nicotine offered by Vaqora Chemicals. With the molecular formula C10H14N2, it has a molar mass of 166.26 g/mol. The IUPAC name is 2,3,4,6-tetradeuterio-5-(1-methylpyrrolidin-2-yl)pyridine. Alternative names: Nicotine D4 and (R,S)-Nicotine-2,4,5,6-D4 (pyridine-D4).

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Danger” with 3 hazard statements. Review the Safety Data Sheet before use.

Its mass shift relative to the unlabelled analyte makes it a dependable internal standard for LC-MS/MS assays, improving accuracy in bioanalysis, therapeutic drug monitoring and method validation. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

We offer rac-Nicotine-d4 in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

LC-MS/MS internal standard
Bioanalytical quantitation
Pharmacokinetic studies

Industries

Related to Nicotine

View every impurity, metabolite and intermediate we list for Nicotine.

Nicotine impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	rac-Nicotine-d4
Catalogue No.	VQ-038617
CAS Number	350818-69-8
IUPAC name	2,3,4,6-tetradeuterio-5-(1-methylpyrrolidin-2-yl)pyridine
Molecular formula	C₁₀H₁₄N₂
Molecular weight	166.26 g/mol
Exact mass	166.1408
Grade	Reference Standard
HSN code	38229090
InChIKey	SNICXCGAKADSCV-MNYIHESISA-N
SMILES	[2H]C1=C(C(=C(N=C1[2H])[2H])C2CCCN2C)[2H]
PubChem CID	45040014

Physical properties
Physical form	Solid
LogP (XLogP3)	1.2
H-bond donors / acceptors	0 / 2
TPSA	16.1 Å²
Synonyms	Nicotine D4, (R,S)-Nicotine-2,4,5,6-D4 (pyridine-D4), Nicotine-d4, (+/-)-Nicotine-d4 (pyridine-d4), (+/-)-Nicotine-2,4,5,6-d4 (pyridine-d4), 3-(1-Methylpyrrolidin-2-yl)(~2~H_4_)pyridine, TMID-0255, (+/-)-Nicotine-2456-d4, ()-Nicotine-2,4,5,6-d4 (pyridine-d4)

Safety & hazard information (GHS)

Toxic

Environmental hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H310Fatal in contact with skin
H411Toxic to aquatic life with long lasting effects

Precautionary statements: P262, P264, P270, P273, P280, P301 + P316, P302 + P352, P316, P321, P330, P361 + P364, P391, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of rac-Nicotine-d4?

The CAS Registry Number of rac-Nicotine-d4 is 350818-69-8. It is also known as Nicotine D4, (R,S)-Nicotine-2,4,5,6-D4 (pyridine-D4), Nicotine-d4.

What is the molecular formula and molecular weight of rac-Nicotine-d4?

rac-Nicotine-d4 has the molecular formula C10H14N2 and a molecular weight of 166.26 g/mol. Its IUPAC name is 2,3,4,6-tetradeuterio-5-(1-methylpyrrolidin-2-yl)pyridine.

What is rac-Nicotine-d4 used for?

rac-Nicotine-d4 is supplied as a characterised reference material related to Nicotine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of rac-Nicotine-d4 can I order?

We supply rac-Nicotine-d4 in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with rac-Nicotine-d4?

Yes. Every lot of rac-Nicotine-d4 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can rac-Nicotine-d4 be shipped internationally?

Yes. rac-Nicotine-d4 is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.