Sacubitril

Name: Sacubitril
Brand: Vaqora Chemicals
SKU: VQ-013784

About Sacubitril

Sacubitril (CAS 149709-62-6) is a process intermediate or related compound of Sacubitril offered by Vaqora Chemicals with a typical assay of 99%. Its molecular formula is C24H29NO5 and its molecular weight is 411.5 g/mol. The IUPAC name is 4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoic acid. It is also known as AHU 377 or AHU-377.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

Process chemists and analysts use it when developing synthetic routes to Sacubitril, tracking process-related impurities and validating analytical methods. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Sacubitril is dispatched with a Certificate of Analysis (COA) to destinations worldwide. This item is currently in stock for prompt dispatch.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development

Industries

Related to Sacubitril

View every impurity, metabolite and intermediate we list for Sacubitril.

Sacubitril impurities

Specifications & identifiers

Chemical identifiers
Product name	Sacubitril
Catalogue No.	VQ-013784
CAS Number	149709-62-6
Other CAS	1369773-39-6, 149690-05-1, 565453-99-8
IUPAC name	4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoic acid
Molecular formula	C₂₄H₂₉NO₅
Molecular weight	411.5 g/mol
Exact mass	411.2046
Grade	Reference Standard
Purity / assay	99%
HSN code	2933
InChIKey	PYNXFZCZUAOOQC-UTKZUKDTSA-N
SMILES	CCOC(=O)[C@H](C)C[C@@H](CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)O
PubChem CID	9811834

Physical properties
Physical form	Solid
LogP (XLogP3)	3.7
H-bond donors / acceptors	2 / 5
TPSA	92.7 Å²
Synonyms	AHU 377, (2R,4S)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester, 3-{[(2S,4R)-5-Ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]carbamoyl}propanoic acid, AHU-377, (2R,4S)-5-(biphenyl-4-yl)-4-((3-carboxypropionyl)amino)-2-methylpentanoic acid ethyl ester, Sacubitril (JAN/USAN/INN), Sacubitril - Bio-X trade mark, (2R,4S)-5-biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methyl-pentanoic acid ethyl ester, (2R,4S)-5-Biphenyl-4-yl-4-(3-carboxypropionylamino)-2-methylpentanoic acid ethyl ester, 4-[[(2S,4R)-1-(4-Biphenylyl)-5-ethoxy-4-methyl-5-oxo-2-pentyl]amino]-4-oxobutanoic Acid

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H317May cause an allergic skin reaction
H319Causes serious eye irritation

Precautionary statements: P261, P264 + P265, P272, P280, P302 + P352, P305 + P351 + P338, P321, P333 + P317, P337 + P317, P362 + P364, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Other grades of CAS 149709-62-6

Sacubitril calcium salt, 98%

CAS: 149709-62-6
Formula: C₂₄H₂₉NO₅
MW: 411.5 g/mol

VQ-008586

Frequently asked questions

What is the CAS number of Sacubitril?

The CAS Registry Number of Sacubitril is 149709-62-6. It is also known as AHU 377, (2R,4S)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester, 3-{[(2S,4R)-5-Ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]carbamoyl}propanoic acid.

What is the molecular formula and molecular weight of Sacubitril?

Sacubitril has the molecular formula C24H29NO5 and a molecular weight of 411.5 g/mol. Its IUPAC name is 4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoic acid.

What is Sacubitril used for?

Sacubitril is supplied as a characterised reference material related to Sacubitril. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Sacubitril can I order?

We supply Sacubitril in Reference Standard (99%) grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Sacubitril?

Yes. Every lot of Sacubitril is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Sacubitril be shipped internationally?

Yes. Sacubitril is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.