Impurity reference standards

Sacubitril impurities & reference standards

Characterised Sacubitril impurities, degradation products and related compounds for analytical method development, validation, QC release and regulatory filings.

92reference materials

1nitrosamine impurities

1isotope-labelled

COAHPLC · NMR · MS on request

Reference Standard

(2E,4S)-5-[1,1'-Biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-pentenoic Acid

CAS: 1015037-46-3
Formula: C₂₃H₂₇NO₄
MW: 381.5 g/mol

VQ-042059

Reference Standard

(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester

CAS: 752174-62-2
Formula: C₂₀H₂₅NO₂
MW: 311.4 g/mol

VQ-012743

Reference Standard

(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride

CAS: 149690-12-0
Formula: C₂₀H₂₆ClNO₂
MW: 347.9 g/mol

In stock

Reference Standard

(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-(2,5-dioxopyrrolidin-1-yl)-2-methylpentanoic acid

CAS: 1639970-62-9
Formula: C₂₂H₂₃NO₄
MW: 365.4 g/mol

VQ-034532

Reference Standard

(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-(4-ethoxy-4-oxobutanamido)-2-methylpentanoic acid

CAS: 149709-49-9
Formula: C₂₄H₂₉NO₅
MW: 411.5 g/mol

VQ-033728

Reference Standard

(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-(4-isopropoxy-4-oxobutanamido)-2-methylpentanoic acid

CAS: 2459446-51-4
Formula: C₂₅H₃₁NO₅
MW: 425.5 g/mol

VQ-027965

Reference Standard

(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid

CAS: 1012341-50-2
Formula: C₂₃H₂₉NO₄
MW: 383.5 g/mol

In stock

Reference Standard

(2R,4S)-Ethyl 5-([1,1'-biphenyl]-4-yl)-4-(4-ethoxy-4-oxobutanamido)-2-methylpentanoate

CAS: 2216747-18-9
Formula: C₂₆H₃₃NO₅
MW: 439.5 g/mol

VQ-033726

Reference Standard

(2R,4S)-Isopropyl 5-([1,1'-biphenyl]-4-yl)-4-(4-isopropoxy-4-oxobutanamido)-2-methylpentanoate

CAS: 2216755-67-6
Formula: C₂₈H₃₇NO₅
MW: 467.6 g/mol

VQ-027966

Reference Standard

(2R,4S)-Sacubitril

CAS: 761373-05-1
Formula: C₂₄H₂₉NO₅
MW: 411.5 g/mol

In stock

Reference Standard

(2R,4S)-Sacubitril Calcium Salt

CAS: 3081732-56-8
Formula: C₂₄H₂₉NO_5.1/2Ca
MW: 431.53 g/mol

VQ-004266

Reference Standard

(2S,4R)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic Acid

CAS: 1012341-54-6
Formula: C₂₃H₂₉NO₄
MW: 383.5 g/mol

VQ-027956

Reference Standard

(2S,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic Acid

CAS: 1012341-52-4
Formula: C₂₃H₂₉NO₄
MW: 383.5 g/mol

VQ-033717

Reference Standard

(2S,4S)-Sacubitril Isomer

CAS: 149709-63-7
Formula: C₂₄H₂₉NO₅
MW: 411.5 g/mol

In stock

Reference Standard

(R,E)-5-([1,1'-Biphenyl]-4-yl)-4-amino-2-methylpent-2-enoic acid

CAS: 2459446-56-9
Formula: C₁₈H₁₉NO₂
MW: 281.3 g/mol

VQ-033723

Reference Standard

(R,E)-Ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoate

CAS: 1817838-91-7
Formula: C₂₅H₃₁NO₄
MW: 409.5 g/mol

VQ-027962

Reference Standard

(R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone

CAS: 131685-53-5
Formula: C₁₃H₁₅NO₃
MW: 233.26 g/mol

VQ-033725

Reference Standard

(R)-1-(1-([1,1'-Biphenyl]-4-yl)-3-chloropropan-2-yl)pyrrolidine-2,5-dione

CAS: 1573000-36-8
Formula: C₁₉H₁₈ClNO₂
MW: 327.8 g/mol

VQ-033720

Reference Standard

(R)-3-([1,1'-Biphenyl]-4-yl)-2-aminopropan-1-ol

CAS: 1426129-52-3
Formula: C₁₅H₁₇NO
MW: 227.3 g/mol

VQ-042070

Reference Standard

(R)-3-([1,1'-Biphenyl]-4-yl)-2-aminopropan-1-ol hydrochloride

CAS: 1573000-33-5
Formula: C₁₅H₁₈ClNO
MW: 263.76 g/mol

VQ-042060

Reference Standard

(R)-4-([1,1'-Biphenyl]-4-ylmethyl)oxazolidin-2-one

CAS: 2829929-67-9
Formula: C₁₆H₁₅NO₂
MW: 253.3 g/mol

VQ-042065

Reference Standard

(R)-Methyl 3-([1,1'-biphenyl]-4-yl)-2-((tert-butoxycarbonyl)amino)propanoate

CAS: 149818-98-4
Formula: C₂₁H₂₅NO₄
MW: 355.4 g/mol

VQ-033722

Reference Standard

(R)-Methyl 3-([1,1'-biphenyl]-4-yl)-2-acetamidopropanoate

CAS: 164460-67-7
Formula: C₁₈H₁₉NO₃
MW: 297.3 g/mol

VQ-033732

Reference Standard

(R)-N-(1-([1,1'-Biphenyl]-4-yl)-3-hydroxypropan-2-yl)acetamide

CAS: 1660147-07-8
Formula: C₁₇H₁₉NO₂
MW: 269.34 g/mol

VQ-033734

Reference Standard

(S)-1-([1,1′-Biphenyl]-4-yl)-3-chloropropan-2-ol

CAS: 1573000-28-8
Formula: C₁₅H₁₅ClO
MW: 246.73 g/mol

VQ-023708

Reference Standard

(Z)-Sacubitril Maleic Acid

CAS: 2751722-77-5
Formula: C₂₄H₂₇NO₅
MW: 409.5 g/mol

VQ-021334

Reference Standard

(αR,γR)-γ-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-methyl-[1,1'-biphenyl]-4-pentanoic Acid

CAS: 1012341-56-8
Formula: C₂₃H₂₉NO₄
MW: 383.5 g/mol

VQ-027957

Reference Standard

[(1R)-2-(Biphenyl-4-yl)-1-formylethyl]carbamic acid tert-butyl ester

CAS: 149709-58-0
Formula: C₂₀H₂₃NO₃
MW: 325.4 g/mol

VQ-027958

1-Ethoxy-1-oxopropan-2-yl)triphenylphosphonium bromide

CAS: 30018-16-7
Formula: C₂₃H₂₄BrO₂P
MW: 443.3 g/mol

VQ-039390

Reference Standard

1,1-Dimethylethyl N-[(1S)-2-[1,1′-biphenyl]-4-yl-1-formylethyl]carbamate

CAS: 182192-86-5
Formula: C₂₀H₂₃NO₃
MW: 325.4 g/mol

VQ-033730

Reference Standard

2,5-Dioxopyrrolidine Sacubitril

CAS: 1038924-97-8
Formula: C₂₄H₂₇NO₄
MW: 393.5 g/mol

In stock

Reference Standard

4-(((2S,4R)-1-([1,1'-Biphenyl]-4-yl)-5-isopropoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid

CAS: 2514965-95-6
Formula: C₂₅H₃₁NO₅
MW: 425.5 g/mol

VQ-027960

Reference Standard

4-((3R,5S)-5-([1,1'-Biphenyl]-4-ylmethyl)-3-methyl-2-oxopyrrolidin-1-yl)-4-oxobutanoic Acid

CAS: 2459446-54-7
Formula: C₂₂H₂₃NO₄
MW: 365.4 g/mol

VQ-033716

Reference Standard

4-((3R,5S)-5-([1,1'-Biphenyl]-4-ylmethyl)-3-methyl-2-oxopyrrolidin-1-yl)-4-oxobutanoic acid

CAS: 2216746-87-9
Formula: C₂₂H₂₃NO₄
MW: 365.4 g/mol

VQ-034533

Reference Standard

4-Iodo-D-phenylalanine

CAS: 62561-75-5
Formula: C₉H₁₀INO₂
MW: 291.09 g/mol

VQ-027291

Reference Standard

Boc-D-4,4-Biphenylalanine

CAS: 128779-47-5
Formula: C₂₀H₂₃NO₄
MW: 341.4 g/mol

VQ-042063

Reference Standard

Ene Sacubitril

CAS: 2957885-24-2
Formula: C₂₄H₂₇NO₅
MW: 409.47 g/mol

VQ-027963

Reference Standard

Ethyl

CAS: 2413471-13-1
Formula: C₂₄H₂₇NO₄
MW: 393.48 g/mol

VQ-042062

Reference Standard

Ethyl (2R,4R)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride

CAS: 2101223-17-8
Formula: C₂₀H₂₆ClNO₂
MW: 347.9 g/mol

VQ-042058

Reference Standard

Ethyl (2S,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride

CAS: 149690-13-1
Formula: C₂₀H₂₆ClNO₂
MW: 347.9 g/mol

VQ-033721

Reference Standard

Ethyl (S,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoate

CAS: 2131788-25-3
Formula: C₂₅H₃₁NO₄
MW: 409.5 g/mol

VQ-033731

Reference Standard

Ethyl 2-(Triphenylphosphoranylidene)Propanoate

CAS: 5717-37-3
Formula: C₂₃H₂₃O₂P
MW: 362.4 g/mol

VQ-033733

Reference Standard

Isopropyl

CAS: 2459446-55-8
Formula: C₂₅H₂₉NO₄
MW: 407.5 g/mol

VQ-033729

Reference Standard

Isopropyl 4-((3R,5S)-5-([1,1'-biphenyl]-4-ylmethyl)-3-methyl-2-oxopyrrolidin-1-yl)-4-oxobutanoate

CAS: 2149600-13-3
Formula: C₂₅H₂₉NO₄
MW: 407.5 g/mol

VQ-033727

Reference Standard

Methyl

CAS: 556828-95-6
Formula: C₁₈H₁₇NO₃
MW: 295.3 g/mol

VQ-033736

Reference Standard

N-[(1R)-2-[1,1′-Biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid 1,1-dimethylethyl ester

CAS: 1426129-50-1
Formula: C₂₀H₂₅NO₃
MW: 327.4 g/mol

VQ-023707

Reference Standard

N-Nitroso Sacubitril Impurity 1

Formula: C₁₈H₁₈N₂O₂
MW: 294.35 g/mol

In stock

Reference Standard

NAP006-06 (Z isomer)

CAS: 1361408-16-3
Formula: C₂₃H₂₇NO₄
MW: 381.5 g/mol

VQ-033718

Reference Standard

Rel-Sacubitril (2R,4R) Isomer

CAS: 766480-48-2
Formula: C₂₄H₂₉NO₅
MW: 411.5 g/mol

VQ-005723

Reference Standard

Rel-Sacubitril (2R,4R) Isomer (Triethanolamine salt)

Formula: C₂₄H₂₉NO₅.C₆H₁₅NO₃
MW: 560.68 g/mol

VQ-005724

Reference Standard

Sacubitril

CAS: 149709-62-6
Formula: C₂₄H₂₉NO₅
MW: 411.5 g/mol

In stock

Reference Standard

Sacubitril (2R,4R) Isomer

CAS: 2259708-00-2
Formula: C₂₄H₂₉NO₅
MW: 411.5 g/mol

In stock

Reference Standard

Sacubitril (2R,4R) Isomer Calcium Salt

CAS: 3081732-59-1
Formula: C₂₄H₂₉NO_5.1/2Ca
MW: 431.53 g/mol

VQ-005853

Reference Standard

Sacubitril (3R,5S)-Pyrrolidinone Impurity

CAS: 1038924-70-7
Formula: C₁₈H₁₉NO
MW: 265.3 g/mol

VQ-023706

Reference Standard

Sacubitril Amino Acid Impurity

CAS: 1038924-71-8
Formula: C₁₈H₂₂ClNO₂
MW: 319.8 g/mol

VQ-005854

Reference Standard

Sacubitril Butyl Ester Impurity of Stage II

Formula: C₂₆H₃₃NO₅
MW: 439.54 g/mol

In stock

Reference Standard

Sacubitril Calcium Salt

CAS: 1369773-39-6
Formula: C₄₈H₅₆CaN₂O₁₀
MW: 861 g/mol

In stock

Reference Standard

Sacubitril cyclized boc impurity

CAS: 1835193-03-7
Formula: C₃₃H₃₈N₂O₅
MW: 542.7 g/mol

VQ-042064

Reference Standard

Sacubitril Diacid Impurity

CAS: 149709-44-4
Formula: C₂₂H₂₅NO₅
MW: 383.4 g/mol

In stock

Reference Standard

Sacubitril Diethyl Ester

CAS: 2376611-98-0
Formula: C₂₆H₃₃NO₅
MW: 439.5 g/mol

In stock

FAQs — Sacubitril impurities

Which Sacubitril impurities do you supply?

We list 92 Sacubitril-related reference materials, including process impurities, degradation products, nitrosamine impurities, stable-isotope-labelled standards and related compounds. Each is supplied with a COA, and characterisation data (HPLC, 1H-NMR, MS, IR) can be provided on request.

What are Sacubitril impurity standards used for?

They are used for analytical method development and validation, impurity identification and quantification, forced-degradation and stability studies, and to support ANDA, DMF and other regulatory submissions under ICH Q3A/Q3B (and ICH M7 for mutagenic impurities).

Can you synthesise a Sacubitril impurity that is not listed?

Yes. Our custom synthesis service can prepare and characterise unlisted impurities, metabolites and labelled analogues from milligram to gram scale. Share the structure or name and required quantity for a quotation.

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Sacubitril impurities & reference standards

FAQs — Sacubitril impurities

Request Sacubitril impurity standards