Sitagliptin Nitrosamine Impurity

Name: Sitagliptin Nitrosamine Impurity
Brand: Vaqora Chemicals
SKU: VQ-005937

About Sitagliptin Nitrosamine Impurity

Vaqora Chemicals supplies Sitagliptin Nitrosamine Impurity, an impurity of Sitagliptin registered under CAS number 2892260-32-9. The compound has the formula C6H6F3N5O, corresponding to a molecular weight of 221.14 g/mol. Its systematic (IUPAC) name is 7-nitroso-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazine. Common synonyms include Sitagliptin Nitroso Impurity and Nitroso-Sitagliptin Intermediate.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Pharmaceutical QC and development laboratories use this impurity standard of Sitagliptin to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

We offer Sitagliptin Nitrosamine Impurity in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide. This item is currently in stock for prompt dispatch.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Sitagliptin

View every impurity, metabolite and intermediate we list for Sitagliptin.

Sitagliptin impurities

Specifications & identifiers

Chemical identifiers
Product name	Sitagliptin Nitrosamine Impurity
Catalogue No.	VQ-005937
CAS Number	2892260-32-9
IUPAC name	7-nitroso-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazine
Molecular formula	C₆H₆F₃N₅O
Molecular weight	221.14 g/mol
Exact mass	221.0524
Grade	Reference Standard
HSN code	38229090
InChIKey	HPLUAAVIJHAQQZ-UHFFFAOYSA-N
SMILES	C1CN2C(=NN=C2C(F)(F)F)CN1N=O
PubChem CID	165984324

Physical properties
Physical form	Solid
LogP (XLogP3)	-0.1
H-bond donors / acceptors	0 / 8
TPSA	63.4 Å²
Synonyms	5,6,7,8-Tetrahydro-7-nitroso-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine, 7-Nitroso-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2 ,4]triazolo[4,3-a]pyrazine, Sitagliptin Nitroso Impurity, Nitroso-Sitagliptin Intermediate, 7-Nitroso-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine, 7-nitroso-3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine, Nitroso-STG-19, 7-Nitroso-3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo-[4,3-a]pyrazine, 1,2,4-Triazolo[4,3-a]pyrazine, 5,6,7,8-tetrahydro-7-nitroso-3-(trifluoromethyl)-, Sitagliptin Nttp Impurity, Sitagliptin Impurity 174, N-NitrosoSitagliptinImpurity

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
H341Suspected of causing genetic defects
H351Suspected of causing cancer

Precautionary statements: P203, P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P317, P318, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Sitagliptin Nitrosamine Impurity?

The CAS Registry Number of Sitagliptin Nitrosamine Impurity is 2892260-32-9. It is also known as 5,6,7,8-Tetrahydro-7-nitroso-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine, 7-Nitroso-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2 ,4]triazolo[4,3-a]pyrazine, Sitagliptin Nitroso Impurity.

What is the molecular formula and molecular weight of Sitagliptin Nitrosamine Impurity?

Sitagliptin Nitrosamine Impurity has the molecular formula C6H6F3N5O and a molecular weight of 221.14 g/mol. Its IUPAC name is 7-nitroso-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazine.

What is Sitagliptin Nitrosamine Impurity used for?

Sitagliptin Nitrosamine Impurity is supplied as a characterised reference material related to Sitagliptin. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Sitagliptin Nitrosamine Impurity can I order?

We supply Sitagliptin Nitrosamine Impurity in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg, 500 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Sitagliptin Nitrosamine Impurity?

Yes. Every lot of Sitagliptin Nitrosamine Impurity is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Sitagliptin Nitrosamine Impurity be shipped internationally?

Yes. Sitagliptin Nitrosamine Impurity is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.